AbstractThis overview reviews seventeen publications between 1995 and 2005. CHE Imray was the first author of eleven of the papers, the senior author of four and a major contributor to two of the publications. The overview should be read in conjunction
with the full copies of the seventeen publications (Appendix 2).
The brain is exquisitely sensitive to oxygen requiring a constant supply of adequately oxygenated blood to function normally. Cerebral oxygen delivery is dynamic, and alters rapidly in response to changes in physiological and pathological stimuli. Interference with cerebral oxygen delivery, either as a result of decreased cerebral blood flow, decreased arterial oxygenation or particulate matter (cerebral microemboli) within the blood can all rapidly result in temporary or permanent loss of function within minutes.
The author has used non-invasive cerebral perfusion imaging techniques, initially in the clinical setting (in clinic, at the bedside and in the operating theatre) and later transferring these methods to the field setting at high altitude. As a result of these studies, new insights into cerebral perfusion have been gained. Novel concepts such as 'virtual altitude' and 'partitioning of arterial and venous volumes' have been developed. New equipment has been designed and developed, such as the recumbent, collapsible, portable exercise bike. Finally new clinical treatments have been developed, including an apparently safe way to treat the high-risk group of patients with crescendo transient ischaemic attacks or mini-strokes, greatly reducing the risk of developing a subsequent major stroke.
The work submitted for consideration for a PhD by publication represents ten years of investigation in two closely inter-related fields. The aim of the submission is to provide a background to the seventeen publications (Appendix 2) allowing them to be seen in context to existing knowledge. Appendix 3 contains twelve additional communications that have either been published, or accepted for publication after the original list of seventeen publications was submitted to the University of Glamorgan. They confirm the author's ongoing interest and contributions to this field of research.
|Date of Award||Nov 2005|
|Supervisor||Bruce Davies (Supervisor) & Damian Bailey (Supervisor)|
- Cerebral circulation