Therapeutic benefits of proning to improve pulmonary gas exchange in severe respiratory failure: Focus on fundamentals of physiology

Ronan M. G. Berg, Jacob Peter Hartmann, Ulrik Winning Iepsen, Regitse Højgaard Christensen, Andreas Ronit, Anne Sofie Andreasen, Damian M. Bailey, Jann Mortensen, Pope L. Moseley, Ronni R. Plovsing

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Abstract

The survival benefit of proning patients with acute respiratory distress syndrome (ARDS) is well established and has recently been found to improve pulmonary gas exchange in patients with COVID-19-associated ARDS (CARDS). This review outlines the physiological implications of transitioning from supine to prone on alveolar ventilation-perfusion (VA/Q) relationships during spontaneous breathing and during general anaesthesia in the healthy state, as well as during invasive mechanical ventilation in patients with ARDS and CARDS. Spontaneously breathing, awake healthy individuals maintain a small vertical VA/Q (ventral-to-dorsal) gradient in the supine position, which is largely neutralised in the prone position, mainly through redistribution of perfusion. In anaesthetised and mechanically ventilated healthy individuals, a vertical VA/Q ratio gradient is present in both postures, but with better VA/Q matching in the prone position. In ARDS and CARDS, the vertical VA/Q gradient in the supine position becomes larger, with intrapulmonary shunting in gravitationally dependent lung regions due to compression atelectasis of the dorsal lung. This is counteracted by proning, mainly through a more homogenous distribution of ventilation combined with a largely unaffected high perfusion dorsally, and a consequent substantial improvement in arterial oxygenation. The data regarding proning as a therapy in patients with CARDS is still limited and whether the associated improvement in arterial oxygenation translates to a survival benefit remains unknown. Proning is nonetheless an attractive and lung protective manoeuvre with the potential benefit of improving life-threatening hypoxaemia in patients with ARDS and CARDS.
Original languageEnglish
Article numberEP089405
Number of pages12
JournalExperimental Physiology
Volume00
Issue number00
Early online date9 Jul 2021
DOIs
Publication statusPublished - 27 Oct 2021

Keywords

  • acute respiratory distress syndrome
  • COVID-19
  • gas exchange
  • gravity
  • respiratory failure
  • SARS CoV2

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