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The Optical Properties of Indocyanine Green suspended in Solution as Observed under Near Infrared LED and LASER Light Conditions. / Curtis, Angharad ; Li, Kang; Roula, Ali; Copner, Nigel.

In: International Journal of Science and Engineering Applications, Vol. 10, No. 5, IJSEA1005.1005, 23.05.2021, p. 80-89.

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Curtis, Angharad ; Li, Kang ; Roula, Ali ; Copner, Nigel. / The Optical Properties of Indocyanine Green suspended in Solution as Observed under Near Infrared LED and LASER Light Conditions. In: International Journal of Science and Engineering Applications. 2021 ; Vol. 10, No. 5. pp. 80-89.

BibTeX

@article{22bc3a7ebd564c8a88fce0658c41a92b,
title = "The Optical Properties of Indocyanine Green suspended in Solution as Observed under Near Infrared LED and LASER Light Conditions",
abstract = "The use of Indocyanine Green (ICG) as a fluorescent marker at Near Infrared (NIR) excitation wavelengths is well established in clinical imaging. Typical systems comprise multiple LED sources for optimal imaging which can result in unnecessary energy transfer to patients and contribute to tissue damage. An experimental setup comprising a 780 nm excitation channel generating up to 10 mW of optical power is used in order to determine if there is potential to exploit the optical properties of ICG, in order to reduce the total excitation power through pulsing. We demonstrate in this work that a single 1.6 Megapixel CMOS camera with quantum efficiency of less than 30% is appropriate to capture both fluorescent and non-fluorescent landmarks at NIR wavelengths. Experimental results verify that all ICG solutions tested yielded detectable fluorescence and that degradation of fluorescence intensity over time is multifaceted.",
keywords = "Fluorescence Imaging, Indocyanine Green (ICG), Fluorescence Endoscopy, In-Vitro Testing, Fluorescence Spectrometry",
author = "Angharad Curtis and Kang Li and Ali Roula and Nigel Copner",
year = "2021",
month = may,
day = "23",
doi = "10.7753/IJSEA1005.1005",
language = "English",
volume = "10",
pages = "80--89",
journal = "International Journal of Science and Engineering Applications",
issn = "2319-7560",
number = "5",

}

RIS

TY - JOUR

T1 - The Optical Properties of Indocyanine Green suspended in Solution as Observed under Near Infrared LED and LASER Light Conditions

AU - Curtis, Angharad

AU - Li, Kang

AU - Roula, Ali

AU - Copner, Nigel

PY - 2021/5/23

Y1 - 2021/5/23

N2 - The use of Indocyanine Green (ICG) as a fluorescent marker at Near Infrared (NIR) excitation wavelengths is well established in clinical imaging. Typical systems comprise multiple LED sources for optimal imaging which can result in unnecessary energy transfer to patients and contribute to tissue damage. An experimental setup comprising a 780 nm excitation channel generating up to 10 mW of optical power is used in order to determine if there is potential to exploit the optical properties of ICG, in order to reduce the total excitation power through pulsing. We demonstrate in this work that a single 1.6 Megapixel CMOS camera with quantum efficiency of less than 30% is appropriate to capture both fluorescent and non-fluorescent landmarks at NIR wavelengths. Experimental results verify that all ICG solutions tested yielded detectable fluorescence and that degradation of fluorescence intensity over time is multifaceted.

AB - The use of Indocyanine Green (ICG) as a fluorescent marker at Near Infrared (NIR) excitation wavelengths is well established in clinical imaging. Typical systems comprise multiple LED sources for optimal imaging which can result in unnecessary energy transfer to patients and contribute to tissue damage. An experimental setup comprising a 780 nm excitation channel generating up to 10 mW of optical power is used in order to determine if there is potential to exploit the optical properties of ICG, in order to reduce the total excitation power through pulsing. We demonstrate in this work that a single 1.6 Megapixel CMOS camera with quantum efficiency of less than 30% is appropriate to capture both fluorescent and non-fluorescent landmarks at NIR wavelengths. Experimental results verify that all ICG solutions tested yielded detectable fluorescence and that degradation of fluorescence intensity over time is multifaceted.

KW - Fluorescence Imaging

KW - Indocyanine Green (ICG)

KW - Fluorescence Endoscopy

KW - In-Vitro Testing

KW - Fluorescence Spectrometry

U2 - 10.7753/IJSEA1005.1005

DO - 10.7753/IJSEA1005.1005

M3 - Article

VL - 10

SP - 80

EP - 89

JO - International Journal of Science and Engineering Applications

JF - International Journal of Science and Engineering Applications

SN - 2319-7560

IS - 5

M1 - IJSEA1005.1005

ER -

ID: 5164871