The influence of hemoconcentration on hypoxic pulmonary vasoconstriction in acute, prolonged, and lifelong hypoxemia

Mike Stembridge; Ryan L. Hoiland; Alexandra M. Williams; Connor A. Howe; Joseph Donnelly; Tony G. Dawkins; Aimee Drane; Michael M. Tymko; Christopher Gasho; James Anholm; Lydia L. Simpson; Jonathan P. Moore; Damian M. Bailey; David B. MacLeod; Philip N. Ainslie

doi:10.1152/ajpheart.00357.2021

The influence of hemoconcentration on hypoxic pulmonary vasoconstriction in acute, prolonged, and lifelong hypoxemia

Mike Stembridge, Ryan L. Hoiland, Alexandra M. Williams, Connor A. Howe, Joseph Donnelly, Tony G. Dawkins, Aimee Drane, Michael M. Tymko, Christopher Gasho, James Anholm, Lydia L. Simpson, Jonathan P. Moore, Damian M. Bailey, David B. MacLeod, Philip N. Ainslie

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Abstract

Red blood cell concentration influences the pulmonary vasculature via direct frictional force and vasoactive signaling, but whether the magnitude of the response is modified with duration of exposure is not known. By assessing the pulmonary vascular response to hemodilution in acute normobaric and prolonged hypobaric hypoxia in lowlanders and lifelong hypobaric hypoxemia in Andean natives, we demonstrated that a reduction in red cell concentration augments the vasoconstrictive effects of hypoxia in lowlanders. In high-altitude natives, hemodilution lowered pulmonary vascular resistance, but a compensatory increase in cardiac output following hemodilution rendered PASP unchanged.

Original language	English
Article number	00357
Pages (from-to)	H738-H747
Number of pages	10
Journal	American Journal of Physiology - Heart and Circulatory Physiology
Volume	321
Issue number	4
Early online date	28 Sept 2021
DOIs	https://doi.org/10.1152/ajpheart.00357.2021
Publication status	Published - 1 Oct 2021

Keywords

hemodilution
hypoxia
hypoxic pulmonary vasoconstriction
pulmonary pressure
viscosity

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10.1152/ajpheart.00357.2021Licence: CC BY

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Stembridge, M., Hoiland, R. L., Williams, A. M., Howe, C. A., Donnelly, J., Dawkins, T. G., Drane, A., Tymko, M. M., Gasho, C., Anholm, J., Simpson, L. L., Moore, J. P., Bailey, D. M., MacLeod, D. B., & Ainslie, P. N. (2021). The influence of hemoconcentration on hypoxic pulmonary vasoconstriction in acute, prolonged, and lifelong hypoxemia. American Journal of Physiology - Heart and Circulatory Physiology, 321(4), H738-H747. Article 00357. https://doi.org/10.1152/ajpheart.00357.2021

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title = "The influence of hemoconcentration on hypoxic pulmonary vasoconstriction in acute, prolonged, and lifelong hypoxemia",

abstract = "Red blood cell concentration influences the pulmonary vasculature via direct frictional force and vasoactive signaling, but whether the magnitude of the response is modified with duration of exposure is not known. By assessing the pulmonary vascular response to hemodilution in acute normobaric and prolonged hypobaric hypoxia in lowlanders and lifelong hypobaric hypoxemia in Andean natives, we demonstrated that a reduction in red cell concentration augments the vasoconstrictive effects of hypoxia in lowlanders. In high-altitude natives, hemodilution lowered pulmonary vascular resistance, but a compensatory increase in cardiac output following hemodilution rendered PASP unchanged.",

keywords = "hemodilution, hypoxia, hypoxic pulmonary vasoconstriction, pulmonary pressure, viscosity",

author = "Mike Stembridge and Hoiland, {Ryan L.} and Williams, {Alexandra M.} and Howe, {Connor A.} and Joseph Donnelly and Dawkins, {Tony G.} and Aimee Drane and Tymko, {Michael M.} and Christopher Gasho and James Anholm and Simpson, {Lydia L.} and Moore, {Jonathan P.} and Bailey, {Damian M.} and MacLeod, {David B.} and Ainslie, {Philip N.}",

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doi = "10.1152/ajpheart.00357.2021",

language = "English",

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Stembridge, M, Hoiland, RL, Williams, AM, Howe, CA, Donnelly, J, Dawkins, TG, Drane, A, Tymko, MM, Gasho, C, Anholm, J, Simpson, LL, Moore, JP, Bailey, DM, MacLeod, DB & Ainslie, PN 2021, 'The influence of hemoconcentration on hypoxic pulmonary vasoconstriction in acute, prolonged, and lifelong hypoxemia', American Journal of Physiology - Heart and Circulatory Physiology, vol. 321, no. 4, 00357, pp. H738-H747. https://doi.org/10.1152/ajpheart.00357.2021

The influence of hemoconcentration on hypoxic pulmonary vasoconstriction in acute, prolonged, and lifelong hypoxemia. / Stembridge, Mike; Hoiland, Ryan L.; Williams, Alexandra M. et al.
In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 321, No. 4, 00357, 01.10.2021, p. H738-H747.

Research output: Contribution to journal › Article › peer-review

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T1 - The influence of hemoconcentration on hypoxic pulmonary vasoconstriction in acute, prolonged, and lifelong hypoxemia

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AU - Howe, Connor A.

AU - Donnelly, Joseph

AU - Dawkins, Tony G.

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AU - Anholm, James

AU - Simpson, Lydia L.

AU - Moore, Jonathan P.

AU - Bailey, Damian M.

AU - MacLeod, David B.

AU - Ainslie, Philip N.

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KW - hemodilution

KW - hypoxia

KW - hypoxic pulmonary vasoconstriction

KW - pulmonary pressure

KW - viscosity

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IS - 4

M1 - 00357

ER -

The influence of hemoconcentration on hypoxic pulmonary vasoconstriction in acute, prolonged, and lifelong hypoxemia

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Keywords

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