Synthesis and Stereochemical Assignment of (+)-Chamuvarinin

Raghava Vanga, G. J. Florence, J. Morris, R. Murray, J. Osler, T. Smith

Research output: Contribution to journalArticlepeer-review


A stereocontrolled total synthesis of (+)-chamuvarinin, isolated from the root extract of Uvaria Chamae, utilizes a convergent modular strategy to construct the adjacently linked C15-C28 ether array, followed by a late-stage Julia-Kocienski olefination to append the butenolide motif. This constitutes the first total synthesis of (+)-chamuvarinin, defining the relative and absolute configuration of this unique annonaceous acetogenin.
Original languageEnglish
Pages (from-to)5 - 7
Number of pages2
JournalOrganic Letters
Issue number3
Publication statusPublished - 4 Feb 2011


  • chamuvarinin
  • synthesis and stereochemical


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