Sparse substance p-like immunoreactivity in intervertebral discs: Nerve fibers and endings in the rat

Peter W. Mccarthy

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15 Citations (Scopus)

Abstract

I studied rat lumbar intervertebral discs using a monoclonal antibody to substance P, which revealed immunoreactivity in the periosteum and ligaments adjacent to the intervertebral disc. Fibers containing substance P-like immunoreactivity were also found penetrating and terminating within the annulus fibrosus of both the anterior and posterior intervertebral disc. the maximum depth of penetration was 5 lamellae (annular rings) or approximately one sixth of the depth of the annulus. the terminal structures were not encapsulated (free-nerve endings) and were either branched, looped or both. the majority of fibers were varicose in appearance. Substance P-like immunoreactivity was very minor.

Original languageEnglish
Pages (from-to)664-668
Number of pages5
JournalActa Orthopaedica
Volume64
Issue number6
DOIs
Publication statusPublished - 1993

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