Abstract
I studied rat lumbar intervertebral discs using a monoclonal antibody to substance P, which revealed immunoreactivity in the periosteum and ligaments adjacent to the intervertebral disc. Fibers containing substance P-like immunoreactivity were also found penetrating and terminating within the annulus fibrosus of both the anterior and posterior intervertebral disc. the maximum depth of penetration was 5 lamellae (annular rings) or approximately one sixth of the depth of the annulus. the terminal structures were not encapsulated (free-nerve endings) and were either branched, looped or both. the majority of fibers were varicose in appearance. Substance P-like immunoreactivity was very minor.
Original language | English |
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Pages (from-to) | 664-668 |
Number of pages | 5 |
Journal | Acta Orthopaedica |
Volume | 64 |
Issue number | 6 |
DOIs | |
Publication status | Published - 1993 |