Abstract
1,5,7-Triazabicyclo[4.4.0]dec-1-ene (TBD) and 7-methyl-1,5,7- triazabicyclo[4.4.0]dec-1-ene (MTBD) promote the efficient formation of sulfonium ylides from sulfonium salts in the Corey-Chaykovsky epoxidation of aldehydes and provide excellent yields of the corresponding epoxides. This reaction protocol can be further adapted to allow for the development of both sequential and tandem-oxidation-epoxidation protocols from aldehydes generated in situ by manganese dioxide (MnO2) or barium manganate (BaMnO 4) mediated oxidation reactions.
Original language | English |
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Pages (from-to) | 6196-6202 |
Number of pages | 7 |
Journal | Tetrahedron Letters |
Volume | 69 |
Issue number | 30 |
DOIs | |
Publication status | Published - 29 Jul 2013 |