TY - JOUR
T1 - Self-powered optical fiber biosensor integrated with enzymes for non-invasive glucose sensing
AU - Wen, Xingyue
AU - Yang, Xinghua
AU - Ge, Zhongxuan
AU - Ma, Hongyu
AU - Wang, Rui
AU - Tian, Fengjun
AU - Teng, Pingping
AU - Gao, Shuai
AU - Li, Kang
AU - Zhang, Bo
AU - Sivanathan, Sivagunalan
PY - 2024/3/8
Y1 - 2024/3/8
N2 - To alleviate the discomfort associated with frequent blood glucose detection in diabetic patients, a novel non-invasive tear glucose biosensor has been developed. This involved the design and preparation of a photoelectrochemical probe based on an optical fiber and biological enzymes. One end of the optical fiber connects to a light source, acting as an energy source and imparting, self-powered capability to the biosensor. The opposite end is loaded with nanomaterials and glucose oxidase, designed for insertion into the sample to realize photoelectrochemical sensing. This innovative configuration not only improves the integration of the biosensor but is also suitable for analyzing minuscule voluminal samples. The results show that the proposed biosensor exhibits a linear range from 10 nM to 100 μM, possesses a low detection limit of 4.1 nM and a short response time of 0.7 s. Benefiting from the high selectivity of the enzyme, the proposed biosensor demonstrates excellent resistance to the interference of common tear components. In summary, this work provides a more effective method for non-invasive glucose detection and affords valuable ideas for the design and fabrication of non-invasive and self-powered biosensors.
AB - To alleviate the discomfort associated with frequent blood glucose detection in diabetic patients, a novel non-invasive tear glucose biosensor has been developed. This involved the design and preparation of a photoelectrochemical probe based on an optical fiber and biological enzymes. One end of the optical fiber connects to a light source, acting as an energy source and imparting, self-powered capability to the biosensor. The opposite end is loaded with nanomaterials and glucose oxidase, designed for insertion into the sample to realize photoelectrochemical sensing. This innovative configuration not only improves the integration of the biosensor but is also suitable for analyzing minuscule voluminal samples. The results show that the proposed biosensor exhibits a linear range from 10 nM to 100 μM, possesses a low detection limit of 4.1 nM and a short response time of 0.7 s. Benefiting from the high selectivity of the enzyme, the proposed biosensor demonstrates excellent resistance to the interference of common tear components. In summary, this work provides a more effective method for non-invasive glucose detection and affords valuable ideas for the design and fabrication of non-invasive and self-powered biosensors.
KW - Tear glucose
KW - Self-powered
KW - Enzyme biosensor
U2 - 10.1016/j.bios.2024.116191
DO - 10.1016/j.bios.2024.116191
M3 - Article
C2 - 38460209
SN - 0956-5663
VL - 253
JO - Biosensors and Bioelectronics
JF - Biosensors and Bioelectronics
M1 - 116191
ER -