Sedentary aging increases resting and exercise-induced intramuscular free radical formation

Damian Bailey; Jane McEneny; Odile Mathieu-Costello; Robert R Henry; Philip E James; Joe M McCord; Sylvia Pietri; Ian S. Young; Russell S Richardson

doi:10.1152/japplphysiol.00354.2010

Sedentary aging increases resting and exercise-induced intramuscular free radical formation

Damian Bailey, Jane McEneny, Odile Mathieu-Costello, Robert R Henry, Philip E James, Joe M McCord, Sylvia Pietri, Ian S. Young, Russell S Richardson

Faculty of Life Sciences and Education

Research output: Contribution to journal › Article › peer-review

Abstract

Mitochondrial free radical formation has been implicated as a potential mechanism underlying degenerative senescence, although human data are lacking. Therefore, the present study was designed to examine if resting and exercise-induced intramuscular free radical-mediated lipid peroxidation is indeed increased across the spectrum of sedentary aging.

Original language	English
Pages (from-to)	449 - 456
Number of pages	7
Journal	Journal of Applied Physiology
Volume	109
Issue number	2
DOIs	https://doi.org/10.1152/japplphysiol.00354.2010
Publication status	Published - 27 May 2010

Keywords

electron paramagnetic resonance spectroscopy
spin trapping
mitochondria
lipid peroxidation
free radical theory of aging

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10.1152/japplphysiol.00354.2010

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title = "Sedentary aging increases resting and exercise-induced intramuscular free radical formation",

abstract = "Mitochondrial free radical formation has been implicated as a potential mechanism underlying degenerative senescence, although human data are lacking. Therefore, the present study was designed to examine if resting and exercise-induced intramuscular free radical-mediated lipid peroxidation is indeed increased across the spectrum of sedentary aging.",

keywords = "electron paramagnetic resonance spectroscopy, spin trapping, mitochondria, lipid peroxidation, free radical theory of aging",

author = "Damian Bailey and Jane McEneny and Odile Mathieu-Costello and Henry, {Robert R} and James, {Philip E} and McCord, {Joe M} and Sylvia Pietri and Young, {Ian S.} and Richardson, {Russell S}",

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AU - Bailey, Damian

AU - McEneny, Jane

AU - Mathieu-Costello, Odile

AU - Henry, Robert R

AU - James, Philip E

AU - McCord, Joe M

AU - Pietri, Sylvia

AU - Young, Ian S.

AU - Richardson, Russell S

PY - 2010/5/27

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N2 - Mitochondrial free radical formation has been implicated as a potential mechanism underlying degenerative senescence, although human data are lacking. Therefore, the present study was designed to examine if resting and exercise-induced intramuscular free radical-mediated lipid peroxidation is indeed increased across the spectrum of sedentary aging.

AB - Mitochondrial free radical formation has been implicated as a potential mechanism underlying degenerative senescence, although human data are lacking. Therefore, the present study was designed to examine if resting and exercise-induced intramuscular free radical-mediated lipid peroxidation is indeed increased across the spectrum of sedentary aging.

KW - electron paramagnetic resonance spectroscopy

KW - spin trapping

KW - mitochondria

KW - lipid peroxidation

KW - free radical theory of aging

U2 - 10.1152/japplphysiol.00354.2010

DO - 10.1152/japplphysiol.00354.2010

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SP - 449

EP - 456

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

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Sedentary aging increases resting and exercise-induced intramuscular free radical formation

Abstract

Keywords

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