Preparation and characterization of 6A-polyamine-mono-substituted β-cyclodextrins

Bruce L. May, Suzanna D. Kean, Christopher J. Easton, Stephen F. Lincoln

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73 Citations (Scopus)

Abstract

General syntheses for eleven β-cyclodextrins (cyclomaltoheptaoses) mono-substituted at the C6 position by a polyamine are described. The basis of the synthesis is the reaction of 6A-O-(4-methylphenylsulfonyl)-β-cyclodextrin in the presence of KI in 1-methylpyrrolidin-2-one solution. This produces a clean product and obviates the substantial purification procedures which other preparative methods often entail. Systematic studies of the variations of the P-KaS of the protonated amine groups and the 13C NMR spectra of the modified β-cyclodextrins with pH are reported.

Original languageEnglish
Pages (from-to)3157-3160
Number of pages4
JournalJournal of the Chemical Society - Perkin Transactions 1
Issue number21
DOIs
Publication statusPublished - 7 Nov 1997
Externally publishedYes

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