Nanoporous Aluminosilicate Mediated Synthesis of 2- and 2,2-substituted 2,3-Dihydroquinazolin-4(1H)-ones

Matthew Aldred, Fuxuan Li, Rong Kuang, Owen L. Thomas, Thomas Davies, Stuart H. Taylor, Peter Miedziak, Andrew Graham*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Nanoporous silicate materials, made by an operationally simple evaporation-induced selfassembly (EISA) approach, efficiently catalyze the formation of 2-substituted 2,3-dihydroquinazolin4(1H)-ones from aldehydes and dimethyl acetals. This methodology can be extended to encompass the reaction of ketones and ketals to provide facile access to 2,2-disubstituted and spiro dihydroquinazolin4(1H)-ones in high yields and short reaction times.
Original languageEnglish
Article number155037
Number of pages5
JournalTetrahedron Letters
Volume140
Early online date26 Mar 2024
DOIs
Publication statusE-pub ahead of print - 26 Mar 2024

Keywords

  • Heterogeneous catalysis
  • dihydroquinazolinones
  • cyclocondensation
  • nanoporous aluminosilicates

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