TY - JOUR
T1 - Nanoporous Aluminosilicate-Catalyzed Telescoped Acetalization-Direct Aldol Reactions of Acetals with 1,3-Dicarbonyl Compounds
AU - Davies, Thomas Edward
AU - Taylor, Stuart Hamilton
AU - Graham, Andrew Edward
PY - 2018/11/30
Y1 - 2018/11/30
N2 - Nanoporous aluminosilicate materials, synthesized by an evaporation-induced self-assembly process, catalyze the direct aldol reaction of acyclic acetals with a range of 1,3-dicarbonyl compounds to produce the corresponding aldol addition products in high yield, rather than the expected Knoevenagel elimination products. By carrying out the reaction in the presence of either dimethoxy propane or the corresponding orthoester, it is possible to capitalize on the ability of these aluminosilicate materials to catalyze the corresponding acetalization reaction leading to the development of novel telescoped, acetalization-direct aldol addition reaction protocols
AB - Nanoporous aluminosilicate materials, synthesized by an evaporation-induced self-assembly process, catalyze the direct aldol reaction of acyclic acetals with a range of 1,3-dicarbonyl compounds to produce the corresponding aldol addition products in high yield, rather than the expected Knoevenagel elimination products. By carrying out the reaction in the presence of either dimethoxy propane or the corresponding orthoester, it is possible to capitalize on the ability of these aluminosilicate materials to catalyze the corresponding acetalization reaction leading to the development of novel telescoped, acetalization-direct aldol addition reaction protocols
KW - Addition reaction
KW - Catalysts
KW - Nanoporous materials
KW - Self-assembly
U2 - 10.1021/acsomega.8b02047
DO - 10.1021/acsomega.8b02047
M3 - Article
SN - 2470-1343
VL - 3
SP - 15482
EP - 15491
JO - ACS Omega
JF - ACS Omega
IS - 11
ER -
