Abstract
In this work, we introduce the kinetic framework for modelling synaptic transmission in an existing neural mass model of the thalamocortical circuitry to study Electroencephalogram (EEG) slowing within the alpha frequency band (8–13 Hz), a hallmark of Alzheimer’s disease (AD). Ligand-gated excitatory and inhibitory synapses mediated by AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) and GABA A (gamma-amino-butyric acid) receptors respectively are modelled. Our results show that the concentration of the GABA neurotransmitter acts as a bifurcation parameter, causing the model to switch from a limit cycle mode to a steady state. Further, the retino-geniculate pathway connectivity plays a significant role in modulating the power within the alpha band, thus conforming to research proposing ocular biomarkers in AD. Overall, kinetic modelling of synaptic transmission in neural mass models has enabled a more detailed investigation into the neural correlates underlying abnormal EEG in AD.
| Original language | English |
|---|---|
| Title of host publication | Artificial Neural Networks and Machine Learning -- ICANN 2012 |
| Pages | 645-652 |
| DOIs | |
| Publication status | Published - 19 Sept 2012 |
| Externally published | Yes |
| Event | 22nd International Conference on Artificial Neural Networks - Lausanne, Switzerland Duration: 11 Sept 2012 → 14 Sept 2012 |
Conference
| Conference | 22nd International Conference on Artificial Neural Networks |
|---|---|
| Abbreviated title | ICAN |
| Country/Territory | Switzerland |
| City | Lausanne |
| Period | 11/09/12 → 14/09/12 |
Keywords
- Alpha Rhythm
- Alpha Band
- Thalamic Reticular Nucleus
- Neural Mass Model
- Neurotransmitter Concentration