Integrative focus on the space exposome-integrome: physiological challenges and practical limits of countermeasures beyond low Earth orbit

Damian M. Bailey; Dieter Blottner; Hanns-Christian Gunga; Stefan Schneider; Virginia Wotring; Sarah Baatout; Marco Durante; Rik H. G. Olde Engberink; Nandu Goswami; Martina Heer; Anna-Maria Liphardt; Monica Monici; Francesco Pagnini; Claudia Stern; Jan-Bernd Stukenborg; Tobias Weber; Laurence Vico; Olivier White; Angelique van Ombergen; Alexander Choukér

doi:10.1038/s41526-025-00537-1

Integrative focus on the space exposome-integrome: physiological challenges and practical limits of countermeasures beyond low Earth orbit

Damian M. Bailey^*, Dieter Blottner, Hanns-Christian Gunga, Stefan Schneider, Virginia Wotring, Sarah Baatout, Marco Durante, Rik H. G. Olde Engberink, Nandu Goswami, Martina Heer, Anna-Maria Liphardt, Monica Monici, Francesco Pagnini, Claudia Stern, Jan-Bernd Stukenborg, Tobias Weber, Laurence Vico, Olivier White, Angelique van Ombergen, Alexander Choukér^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Human spaceflight is advancing toward sustainable exploration through initiatives like NASA’s Artemis program, aiming for a lunar outpost and eventual Mars mission. Astronauts face hazards including altered gravity, isolation, and cosmic radiation, linked to over thirty health risks. This review, reflecting ESA community expertise, outlines how understanding the space exposome–integrome interaction can improve risk stratification, guide personalized countermeasures, and address knowledge gaps essential for safe deep-space exploration.

Original language	English
Article number	82
Number of pages	11
Journal	npj Microgravity
Volume	11
DOIs	https://doi.org/10.1038/s41526-025-00537-1
Publication status	Published - 20 Nov 2025

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Bailey, D. M., Blottner, D., Gunga, H.-C., Schneider, S., Wotring, V., Baatout, S., Durante, M., Olde Engberink, R. H. G., Goswami, N., Heer, M., Liphardt, A.-M., Monici, M., Pagnini, F., Stern, C., Stukenborg, J.-B., Weber, T., Vico, L., White, O., van Ombergen, A., & Choukér, A. (2025). Integrative focus on the space exposome-integrome: physiological challenges and practical limits of countermeasures beyond low Earth orbit. npj Microgravity, 11, Article 82. https://doi.org/10.1038/s41526-025-00537-1

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title = "Integrative focus on the space exposome-integrome: physiological challenges and practical limits of countermeasures beyond low Earth orbit",

abstract = "Human spaceflight is advancing toward sustainable exploration through initiatives like NASA{\textquoteright}s Artemis program, aiming for a lunar outpost and eventual Mars mission. Astronauts face hazards including altered gravity, isolation, and cosmic radiation, linked to over thirty health risks. This review, reflecting ESA community expertise, outlines how understanding the space exposome–integrome interaction can improve risk stratification, guide personalized countermeasures, and address knowledge gaps essential for safe deep-space exploration.",

author = "Bailey, {Damian M.} and Dieter Blottner and Hanns-Christian Gunga and Stefan Schneider and Virginia Wotring and Sarah Baatout and Marco Durante and {Olde Engberink}, {Rik H. G.} and Nandu Goswami and Martina Heer and Anna-Maria Liphardt and Monica Monici and Francesco Pagnini and Claudia Stern and Jan-Bernd Stukenborg and Tobias Weber and Laurence Vico and Olivier White and {van Ombergen}, Angelique and Alexander Chouk{\'e}r",

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doi = "10.1038/s41526-025-00537-1",

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Bailey, DM, Blottner, D, Gunga, H-C, Schneider, S, Wotring, V, Baatout, S, Durante, M, Olde Engberink, RHG, Goswami, N, Heer, M, Liphardt, A-M, Monici, M, Pagnini, F, Stern, C, Stukenborg, J-B, Weber, T, Vico, L, White, O, van Ombergen, A & Choukér, A 2025, 'Integrative focus on the space exposome-integrome: physiological challenges and practical limits of countermeasures beyond low Earth orbit', npj Microgravity, vol. 11, 82. https://doi.org/10.1038/s41526-025-00537-1

TY - JOUR

T1 - Integrative focus on the space exposome-integrome: physiological challenges and practical limits of countermeasures beyond low Earth orbit

AU - Bailey, Damian M.

AU - Blottner, Dieter

AU - Gunga, Hanns-Christian

AU - Schneider, Stefan

AU - Wotring, Virginia

AU - Baatout, Sarah

AU - Durante, Marco

AU - Olde Engberink, Rik H. G.

AU - Goswami, Nandu

AU - Heer, Martina

AU - Liphardt, Anna-Maria

AU - Monici, Monica

AU - Pagnini, Francesco

AU - Stern, Claudia

AU - Stukenborg, Jan-Bernd

AU - Weber, Tobias

AU - Vico, Laurence

AU - White, Olivier

AU - van Ombergen, Angelique

AU - Choukér, Alexander

PY - 2025/11/20

Y1 - 2025/11/20

N2 - Human spaceflight is advancing toward sustainable exploration through initiatives like NASA’s Artemis program, aiming for a lunar outpost and eventual Mars mission. Astronauts face hazards including altered gravity, isolation, and cosmic radiation, linked to over thirty health risks. This review, reflecting ESA community expertise, outlines how understanding the space exposome–integrome interaction can improve risk stratification, guide personalized countermeasures, and address knowledge gaps essential for safe deep-space exploration.

AB - Human spaceflight is advancing toward sustainable exploration through initiatives like NASA’s Artemis program, aiming for a lunar outpost and eventual Mars mission. Astronauts face hazards including altered gravity, isolation, and cosmic radiation, linked to over thirty health risks. This review, reflecting ESA community expertise, outlines how understanding the space exposome–integrome interaction can improve risk stratification, guide personalized countermeasures, and address knowledge gaps essential for safe deep-space exploration.

U2 - 10.1038/s41526-025-00537-1

DO - 10.1038/s41526-025-00537-1

M3 - Review article

C2 - 41266377

SN - 2373-8065

VL - 11

JO - npj Microgravity

JF - npj Microgravity

M1 - 82

ER -

Integrative focus on the space exposome-integrome: physiological challenges and practical limits of countermeasures beyond low Earth orbit

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