Abstract
Acyclic acetals and ketals undergo transacetalisation in the presence of catalytic quantities of indium(III) triflate (In(OTf) 3) and diols or triols under solvent-free conditions to generate the corresponding cyclic acetals and ketals in excellent yield. The methodology has been further developed to encompass a tandem acetalisation-acetal exchange protocol, which provides a facile and high yielding route to cyclic ketals from unreactive ketones under very mild reaction conditions.
Original language | English |
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Pages (from-to) | 7775-7781 |
Number of pages | 7 |
Journal | Tetrahedron Letters |
Volume | 68 |
Issue number | 38 |
DOIs | |
Publication status | Published - 23 Sep 2012 |
Keywords
- Glycerol valorisation
- Indium(III) triflate
- Solvent-free reactions
- Tandem reaction protocol
- Transacetalisation