Indium triflate mediated tandem acetalisation-acetal exchange reactions under solvent-free conditions

Brendan M. Smith, Andrew E. Graham*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Acyclic acetals and ketals undergo exchange reactions in the presence of catalytic quantities of indium(III) triflate and diols to generate the corresponding cyclic acetals and ketals in excellent yield. The protocol is rapid, employs mild conditions and can be adapted to employ solvent-free reaction conditions. We have further developed this methodology to encompass a tandem acetalisation-acetal exchange protocol which provides facile access to cyclic ketals from unreactive ketones also under very mild, solvent-free reaction conditions. 

Original languageEnglish
Pages (from-to)6281-6283
Number of pages3
JournalTetrahedron Letters
Volume52
Issue number47
DOIs
Publication statusPublished - 23 Nov 2011

Keywords

  • Acetal exchange
  • Cyclic acetals and ketals
  • Indium triflate
  • Solvent-free reactions
  • Tandem reaction protocol

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