Impaired cerebral blood flow regulation and cognition in male football players

Christopher Marley, Thomas Owens, Hayato Tsukamoto, Benjamin Stacey, Robin Corkill, Damian Bailey

Research output: Contribution to journalArticlepeer-review

Abstract

Football players are at increased risk of neurodegeneration, the likely consequence of repetitive mechanical trauma caused by heading the ball. However, to what extent a history of heading the ball affects cerebral blood flow (CBF) regulation and its potential relationship to cognitive impairment is unknown. To address this, we recruited 16 concussion-free male amateur football players (age: 25 ± 6 y) with a history of heading the ball (18 ± 6 y) and 18 sex, age, education and activity-matched controls with no prior history of contact sport participation or concussion. Cerebral perfusion was measured at rest and in response to both hyper/hypocapnia to determine cerebrovascular reactivity to carbon dioxide (CVRCO2HYPER/HYPO) using transcranial doppler ultrasound and capnography, with the sum reflecting the cerebral vasomotor range. Cognition and visuo-motor coordination were assessed using the Montreal cognitive assessment (MoCA) and the Grooved Pegboard Dexterity Test (GPD), respectively. While no differences in cerebral perfusion were observed (P = 0.938), CVRCO2HYPER/HYPO (P = 0.038/P = 0.025), cerebral vasomotor range (P = 0.002), MoCA (P = 0.027) and GPD performance (dominant hand, P = < 0.001) were consistently lower in the players compared to controls. These findings are the first to demonstrate that CBF regulation and cognition are collectively impaired in male football players with history of heading the ball, which may contribute to neurodegeneration.
Original languageEnglish
Article number14018
Pages (from-to)1908-1913
Number of pages6
JournalScandinavian Journal of Medicine and Science in Sports
Volume31
Issue number10
Early online date7 Jul 2021
DOIs
Publication statusPublished - 17 Jul 2021

Keywords

  • cerebral blood flow
  • cognition
  • football
  • soccer
  • traumatic brain injury

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