Haemostatic response to hypoxaemic/exercise stress: the dilemma of plasma volume correction

Kevin Evans, Lewis Fall, Damian Bailey, Michael H Lewis

Research output: Contribution to journalArticlepeer-review


Patients with arterial occlusive disease are typically hypoxaemic, and exercise is prescribed for rehabilitation. Both stressors independently contract plasma volume (PV), which may influence clinical interpretation of a patient's thrombogenicity. The aim of the study was to emphasise the conceptual significance of PV correction.

Methods and Results
Venous plasma samples were obtained from 18 healthy men at rest in normoxia for the measurement of fibrinogen, prothrombin (PT), thrombin (TT) and activated partial thromboplastin (aPTT) times. Additional samples were obtained in hypoxia (12% oxygen) after 6 h of rest and immediately after a maximal exercise challenge. Haemostatic parameters were expressed before and after volume-shift correction. Passive hypoxia reduced PV by 3±5% (p0.05). Likewise, the lack of change in absolute values for PT and TT (pandgt;0.05) translated into an elongation after correction (pandlt;0.05).

These findings highlight the important, but previously ignored, interpretive implications of PV correction when haemostasis is assessed
Original languageEnglish
Pages (from-to)269 - 271
Number of pages2
JournalJournal of Clinical Pathology
Issue number3
Publication statusPublished - 7 Jan 2011


  • hypoxaemic/exercise stress
  • plasma volume correction


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