Genomic Assemblies of Members of Burkholderia and Related Genera as a Resource for Natural Product Discovery

Alex J. Mullins, Cerith Jones, Matthew J. Bull, Gordon Webster, Julian Parkhill, Thomas R. Connor, James A. H. Murray, Gregory L. Challis, Eshwar Mahenthiralingam

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    Abstract

    The genomes of 450 members of Burkholderiaceae, isolated from clinical and environmental sources, were sequenced and assembled as a resource for genome mining. Genomic analysis of the collection has enabled the identification of multiple metabolites and their biosynthetic gene clusters, including the antibiotics gladiolin, icosalide A, enacyloxin, and cepacin A.
    Original languageEnglish
    Article numbere00485
    Number of pages17
    JournalMicrobiology Resource Announcements
    Volume9
    Issue number42
    DOIs
    Publication statusPublished - 15 Oct 2020

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