Evidence to support the peripheral branching of primary afferent C-fibres in the rat: an in vitro intracellular electrophysiological study

Peter W. McCarthy*, Elizabeth Prabhakar, Sally N. Lawson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Intracellular voltage recordings were made in vitro at 36.5 ± 1°C from 35 rat lumbar dorsal root ganglion (DRG) neurones with a peripheral conduction velocity (CV) in the C-fibre range (0.3-2.2 m/s). The peripheral nerve (PN) was stimulated in one of three different ways, each delivering single stimuli (0.1-1 ms duration, 2-3-times threshold; maximum 50 V) at a low frequency (0.3 Hz). With each of the three stimulation methods used here a similar proportion of cells (approximately 30%) showed changes, either an abrupt latency change or a soma invasion by two action potentials (APs). Both of these changes were consistent with branching of primary afferent C-fibres in the PN.

Original languageEnglish
Pages (from-to)79-84
Number of pages6
JournalBrain Research
Volume704
Issue number1
DOIs
Publication statusPublished - 15 Dec 1995

Keywords

  • Dichotomizing axon
  • Nonmyelinated nerve fibre
  • Primary afferent fibre

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