Efficient oxidation-Wittig olefination-Diels-Alder multicomponent reactions of α-hydroxyketones

Geraint H. Harris; Andrew E. Graham

doi:10.1016/j.tetlet.2010.10.121

Efficient oxidation-Wittig olefination-Diels-Alder multicomponent reactions of α-hydroxyketones

Geraint H. Harris, Andrew E. Graham

Faculty of Computing, Engineering and Science

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

α-Hydroxyketones undergo efficient tandem oxidation-Wittig olefination reactions in the presence of an oxidant to produce high yields of γ-ketocrotonate products. On carrying out the oxidation-Wittig olefination reaction in the presence of 2,3-dimethyl-1,3-butadiene, a novel multicomponent reaction sequence provides access to cycloadducts in high yield.

Original language	English
Pages (from-to)	6890-6892
Number of pages	3
Journal	Tetrahedron Letters
Volume	51
Issue number	52
DOIs	https://doi.org/10.1016/j.tetlet.2010.10.121
Publication status	Published - 29 Dec 2010

Access to Document

10.1016/j.tetlet.2010.10.121Licence: CC BY-NC-ND

Cite this

@article{99ecf0c9f344440ebb36dfebe76c2db0,

title = "Efficient oxidation-Wittig olefination-Diels-Alder multicomponent reactions of α-hydroxyketones",

abstract = "α-Hydroxyketones undergo efficient tandem oxidation-Wittig olefination reactions in the presence of an oxidant to produce high yields of γ-ketocrotonate products. On carrying out the oxidation-Wittig olefination reaction in the presence of 2,3-dimethyl-1,3-butadiene, a novel multicomponent reaction sequence provides access to cycloadducts in high yield. ",

author = "Harris, {Geraint H.} and Graham, {Andrew E.}",

year = "2010",

month = dec,

day = "29",

doi = "10.1016/j.tetlet.2010.10.121",

language = "English",

volume = "51",

pages = "6890--6892",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier",

number = "52",

}

TY - JOUR

T1 - Efficient oxidation-Wittig olefination-Diels-Alder multicomponent reactions of α-hydroxyketones

AU - Harris, Geraint H.

AU - Graham, Andrew E.

PY - 2010/12/29

Y1 - 2010/12/29

N2 - α-Hydroxyketones undergo efficient tandem oxidation-Wittig olefination reactions in the presence of an oxidant to produce high yields of γ-ketocrotonate products. On carrying out the oxidation-Wittig olefination reaction in the presence of 2,3-dimethyl-1,3-butadiene, a novel multicomponent reaction sequence provides access to cycloadducts in high yield.

AB - α-Hydroxyketones undergo efficient tandem oxidation-Wittig olefination reactions in the presence of an oxidant to produce high yields of γ-ketocrotonate products. On carrying out the oxidation-Wittig olefination reaction in the presence of 2,3-dimethyl-1,3-butadiene, a novel multicomponent reaction sequence provides access to cycloadducts in high yield.

U2 - 10.1016/j.tetlet.2010.10.121

DO - 10.1016/j.tetlet.2010.10.121

M3 - Article

AN - SCOPUS:78650677199

SN - 0040-4039

VL - 51

SP - 6890

EP - 6892

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 52

ER -

Efficient oxidation-Wittig olefination-Diels-Alder multicomponent reactions of α-hydroxyketones

Abstract

Access to Document

Fingerprint

Cite this