Abstract
PURPOSE: To demonstrate the application of Mescher-Garwood (MEGA) point-resolved spectroscopy sequence (PRESS) editing to the detection of lactate in the brain at 3T and to investigate changes in lactate concentration associated with inspiratory gas challenges.
MATERIALS AND METHODS: Edited lactate measurements were made in six healthy volunteers while the subjects breathed normoxic (21% O(2)), hypoxic (12% O(2)), and hyperoxic (40% O(2)) gas mixtures. Lactate concentration was quantified relative to the unsuppressed water signal from the same volume.
RESULTS: Lactate concentration was elevated in all subjects during hypoxia in a highly significant fashion (mean increase = 39%; P = 0.0003). There was no significant change seen in hyperoxia.
CONCLUSION: MEGA-PRESS editing at 3T is sufficiently sensitive to detect lactate in the healthy brain with good signal-to-noise ratio (SNR), and can be used to investigate changes in cerebral metabolism arising during inspiratory gas challenges.
Original language | English |
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Pages (from-to) | 320-5 |
Number of pages | 6 |
Journal | Journal of Magnetic Resonance Imaging |
Volume | 32 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1 Aug 2010 |
Keywords
- mrs
- lactate
- hypoxia
- mega press
- hyperoxia