The genetic structure of human populations is extraordinarily complex and of fundamental importance to studies of anthropology, evolution, and medicine. As increasingly many individuals are of mixed origin, there is an unmet need for tools that can infer multiple origins. Misclassification of such individuals can lead to incorrect and costly misinterpretations of genomic data, primarily in disease studies and drug trials. We present an advanced tool to infer ancestry that can identify the biogeographic origins of highly mixed individuals. reAdmix can incorporate individual's knowledge of ancestors (e.g. having some ancestors from Turkey or a Scottish grandmother). reAdmix is an online tool available at http://chcb.saban-chla.usc.edu/reAdmix/.
|Number of pages||11|
|Publication status||Published - 18 Jun 2015|
|Event||VarI Special Interest Group Meeting: Identification and annotation of genetic variants in the context of structure, function, and disease - John B. Hynes Memorial Convention Center, Boston, United States|
Duration: 12 Jul 2014 → 12 Jul 2014
- Ancestry prediction
- Differential evolution
- Geographical origin