Differential Evolution approach to detect recent admixture

Konstantin Kozlov, Dmitri Chebotarev, Mehedi Hassan, Martin Triska, Petr Triska, Pavel Flegontov, Tatiana V. Tatarinova*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)
21 Downloads (Pure)

Abstract

The genetic structure of human populations is extraordinarily complex and of fundamental importance to studies of anthropology, evolution, and medicine. As increasingly many individuals are of mixed origin, there is an unmet need for tools that can infer multiple origins. Misclassification of such individuals can lead to incorrect and costly misinterpretations of genomic data, primarily in disease studies and drug trials. We present an advanced tool to infer ancestry that can identify the biogeographic origins of highly mixed individuals. reAdmix can incorporate individual's knowledge of ancestors (e.g. having some ancestors from Turkey or a Scottish grandmother). reAdmix is an online tool available at http://chcb.saban-chla.usc.edu/reAdmix/.

Original languageEnglish
Article numberS9
Number of pages11
JournalBMC Genomics
Volume16
Issue number8
DOIs
Publication statusPublished - 18 Jun 2015
Externally publishedYes
EventVarI Special Interest Group Meeting: Identification and annotation of genetic variants in the context of structure, function, and disease - John B. Hynes Memorial Convention Center, Boston, United States
Duration: 12 Jul 201412 Jul 2014

Keywords

  • Admixture
  • Ancestry prediction
  • Differential evolution
  • Geographical origin

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