Computational analyses of miRNAs from transcriptome of anti-malarial plant -Artemisia annua.

Tatiana Tatarinova, Álvaro L Pérez-Quintero, Gaurav Sablok, Touqeer Ahmad, Ana Conesa, Camilo López

Research output: Contribution to journalArticlepeer-review


We predicted and analyzed miRNAs precursors and targets using transcriptome of sweet wormwood (Artemisia annua L.), which is a source of an anti-malarial agent artemisinin. Among predicted miRNA targets, 29 (57%) correspond to unknown proteins, 5 (10%) to SQUAMOSA promoter-binding protein, 3 (6%) to Transport Inhibitor Response 1 protein; all other categories comprise the remaining 27% of the sequences. These targets are involved in response to copper deficiency, involved in copper homeostasis, mediating Aux/IAA proteins proteasomal degradation and auxin-regulated transcription. Repression of auxin signaling restricts growth of bacteria P. syringae, suggesting importance of miRNA-mediated suppression of auxin signaling in bacterial resistance.
Original languageEnglish
JournalBiotechnology Letters
Publication statusPublished - 31 Dec 2011


  • mirna
  • bioinformatics


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