Combined Fluorescence and Bright Field Imaging via a Single CMOS Detector Without Filters to Improve on Patient Safety during Endoscopic Procedures

Angharad Curtis, Kang Li, Ali Roula, Nigel Copner

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Abstract

Many endoscopic systems combine white light and NIR light via LED multiplexing in order to image tissue stained with Near Infrared (NIR) fluorescent markers such as Indocyanine Green (ICG). This can result in unnecessary in-vivo energy exposure which can cause irreversible damage to tissue. A simple, single detector system is proposed in this work comprising a single excitation channel at a wavelength of 780nm. We have demonstrated that a single 1.6 Megapixel CMOS camera with quantum efficiency of less than 30% is appropriate to capture both fluorescent and non-fluorescent landmarks at NIR wavelengths. Experimental results indicate that a LASER source generating between up to 10mW of optical power at 780nm could be considered as an alternative to LED.
Original languageEnglish
Article number040303
Number of pages9
JournalJournal of Biomedical Photonics & Engineering
Volume6
Issue number4
DOIs
Publication statusPublished - 31 Dec 2020

Keywords

  • Fluorescence Endoscopy
  • Fluorophore Imaging
  • Indocyanine Green
  • Illumination and Detection

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