Choline acetyltransferase-like immunoreactivity in small diameter neurones of the rat dorsal root ganglion

Holger Sann*, Peter W. McCarthy, Michael Mäder, Michael Schemann

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)

Abstract

In the rat choline acetyltransferase (ChAT)-like immunoreactivity (ChAT-LI) was demonstrated in the dorsal root ganglion (DRG), in the superficial spinal cord and in the subepithelial layer of the ureter using immunohistochemical techniques. In the L1 DRG, 66% of the neurones were ChAT-LI. They did not express neurofilament immunoreactivity (RT97 negative) but could also contain calcitonin gene-related peptide-like immunoreactivity (CGRP-LI). In the superficial spinal cord and in the subepithelial plexus of the ureter - both areas where high numbers of fine afferent fibres have been demonstrated - CGRP-LI and ChAT-LI were co-distributed, indicating that ChAT can be found in the peripheral and central endings of small afferents. The data provide morphological evidence that a substantial proportion of afferent fibres are cholinergic.

Original languageEnglish
Pages (from-to)17-20
Number of pages4
JournalNeuroscience Letters
Volume198
Issue number1
DOIs
Publication statusPublished - 22 Sept 1995

Keywords

  • Calcitonin gene-related peptide
  • Choline acetyltransferase
  • Dorsal root ganglion
  • Rat
  • Spinal cord
  • Ureter

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