Changes in cerebral vascular reactivity and structure following prolonged exposure to high altitude in humans

Glen E. Foster*, Jodie Davies-Thompson, Paolo B. Dominelli, Manraj K.S. Heran, Joseph Donnelly, Gregory R. duManoir, Philip N. Ainslie, Alexander Rauscher, A. William Sheel

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    8 Citations (Scopus)
    18 Downloads (Pure)


    Although high-altitude exposure can lead to neurocognitive impairment, even upon return to sea level, it remains unclear the extent to which brain volume and regional cerebral vascular reactivity (CVR) are altered following high-altitude exposure. The purpose of this study was to simultaneously determine the effect of 3 weeks at 5050 m on: (1) structural brain alterations; and (2) regional CVR after returning to sea level for 1 week. Healthy human volunteers (n = 6) underwent baseline and follow-up structural and functional magnetic resonance imaging (MRI) at rest and during a CVR protocol (end-tidal PCO2 reduced by -10, -5 and increased by +5, +10, and +15 mmHg from baseline). CVR maps (% mmHg-1) were generated using BOLD MRI and brain volumes were estimated. Following return to sea level, whole-brain volume and gray matter volume was reduced by 0.4 ± 0.3% (P < 0.01) and 2.6 ± 1.0% (P < 0.001), respectively; white matter was unchanged. Global gray matter CVR and white matter CVR were unchanged following return to sea level, but CVR was selectively increased (P < 0.05) in the brainstem (+30 ± 12%), hippocampus (+12 ± 3%), and thalamus (+10 ± 3%). These changes were the result of improvement and/or reversal of negative CVR to positive CVR in these regions. Three weeks of high-altitude exposure is reflected in loss of gray matter volume and improvements in negative CVR.

    Original languageEnglish
    Article numbere12647
    JournalPhysiological Reports
    Issue number12
    Publication statusPublished - 1 Jan 2015


    • Cerebral atrophy
    • Cerebral vascular reactivity
    • High altitude


    Dive into the research topics of 'Changes in cerebral vascular reactivity and structure following prolonged exposure to high altitude in humans'. Together they form a unique fingerprint.

    Cite this