Cerebral Blood Flow Responses to Autonomic Dysreflexia in Humans with Spinal Cord Injury

Aaron A. Phillips; Philip N. Ainslie; Darren E.R. Warburton; Andrei V. Krassioukov

doi:10.1089/neu.2015.3871

Cerebral Blood Flow Responses to Autonomic Dysreflexia in Humans with Spinal Cord Injury

Aaron A. Phillips, Philip N. Ainslie, Darren E.R. Warburton, Andrei V. Krassioukov^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Autonomic dysreflexia (AD) is a life-threatening episode of transient hypertension affecting up to 90% of those with high-level spinal cord injury (SCI), and can lead to cerebral hemorrhage. Due to the nature of this medical emergency, cerebral blood flow (CBF) has not been recorded during AD. Beat-by-beat blood pressure (BP) and CBF velocity of the middle cerebral artery were measured during spontaneous AD episodes in four motor complete cervical SCI patients. Mean arterial BP increased during AD (66 ± 11 vs. 83 ± 10 mm Hg; p = 0.004), whereas CBF (76 ± 4 vs. 74 ± 4 cm · sec^-1) and end-tidal partial pressure of carbon dioxide (P_ETCO₂) (35 ± 1 vs. 34 ± 3 mm Hg) were maintained. These preliminary data indicate that the brain may effectively buffer moderate episodes of AD.

Original language	English
Pages (from-to)	315-318
Number of pages	4
Journal	Journal of Neurotrauma
Volume	33
Issue number	3
DOIs	https://doi.org/10.1089/neu.2015.3871
Publication status	Published - 1 Feb 2016

Keywords

autonomic dysfunction
cerebrovascular
paraplegia
tetraplegia

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title = "Cerebral Blood Flow Responses to Autonomic Dysreflexia in Humans with Spinal Cord Injury",

abstract = "Autonomic dysreflexia (AD) is a life-threatening episode of transient hypertension affecting up to 90% of those with high-level spinal cord injury (SCI), and can lead to cerebral hemorrhage. Due to the nature of this medical emergency, cerebral blood flow (CBF) has not been recorded during AD. Beat-by-beat blood pressure (BP) and CBF velocity of the middle cerebral artery were measured during spontaneous AD episodes in four motor complete cervical SCI patients. Mean arterial BP increased during AD (66 ± 11 vs. 83 ± 10 mm Hg; p = 0.004), whereas CBF (76 ± 4 vs. 74 ± 4 cm · sec-1) and end-tidal partial pressure of carbon dioxide (PETCO2) (35 ± 1 vs. 34 ± 3 mm Hg) were maintained. These preliminary data indicate that the brain may effectively buffer moderate episodes of AD.",

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AU - Phillips, Aaron A.

AU - Ainslie, Philip N.

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AU - Krassioukov, Andrei V.

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N2 - Autonomic dysreflexia (AD) is a life-threatening episode of transient hypertension affecting up to 90% of those with high-level spinal cord injury (SCI), and can lead to cerebral hemorrhage. Due to the nature of this medical emergency, cerebral blood flow (CBF) has not been recorded during AD. Beat-by-beat blood pressure (BP) and CBF velocity of the middle cerebral artery were measured during spontaneous AD episodes in four motor complete cervical SCI patients. Mean arterial BP increased during AD (66 ± 11 vs. 83 ± 10 mm Hg; p = 0.004), whereas CBF (76 ± 4 vs. 74 ± 4 cm · sec-1) and end-tidal partial pressure of carbon dioxide (PETCO2) (35 ± 1 vs. 34 ± 3 mm Hg) were maintained. These preliminary data indicate that the brain may effectively buffer moderate episodes of AD.

AB - Autonomic dysreflexia (AD) is a life-threatening episode of transient hypertension affecting up to 90% of those with high-level spinal cord injury (SCI), and can lead to cerebral hemorrhage. Due to the nature of this medical emergency, cerebral blood flow (CBF) has not been recorded during AD. Beat-by-beat blood pressure (BP) and CBF velocity of the middle cerebral artery were measured during spontaneous AD episodes in four motor complete cervical SCI patients. Mean arterial BP increased during AD (66 ± 11 vs. 83 ± 10 mm Hg; p = 0.004), whereas CBF (76 ± 4 vs. 74 ± 4 cm · sec-1) and end-tidal partial pressure of carbon dioxide (PETCO2) (35 ± 1 vs. 34 ± 3 mm Hg) were maintained. These preliminary data indicate that the brain may effectively buffer moderate episodes of AD.

KW - autonomic dysfunction

KW - cerebrovascular

KW - paraplegia

KW - tetraplegia

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DO - 10.1089/neu.2015.3871

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Cerebral Blood Flow Responses to Autonomic Dysreflexia in Humans with Spinal Cord Injury

Abstract

Keywords

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