Cardiopulmonary fitness predicts postoperative major morbidity after esophagectomy for patients with cancer

Neil Patel, Arfon G. Powell*, Jenni R. Wheat, Christopher Brown, Ian R. Appadurai, Richard G. Davies, Damian M. Bailey, Wyn G. Lewis

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

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    Abstract

    Surgery for radical treatment of esophageal cancer (EC) carries significant inherent risk. The objective identification of patients who are at high risk of complications is of importance. In this study the prognostic value of cardiopulmonary fitness variables (CPF) derived from cardiopulmonary exercise testing (CPET) was assessed in patients undergoing potentially curative surgery for EC within an enhanced recovery program. OC patients underwent preoperative CPET using automated breath-by-breath respiratory gas analysis, with measurements taken during a ramped exercise test on a bicycle. The prognostic value of VO2Peak, Anaerobic Threshold (AT) and VE/VCO2 derived from CPET were studied in relation to post-operative morbidity, which was collected prospectively, and overall survival. Consecutive 120 patients were included for analysis (median age 65 years, 100 male, 75 neoadjuvant therapy). Median AT in the cohort developing major morbidity (Clavien–Dindo classification >2) was 10.4 mL/kg/min compared with 11.3 mL/kg/min with no major morbidity (P = 0.048). Median AT in the cohort developing major morbidity was 17.0 mL/kg/min compared with 18.7 mL/kg/min in the cohort (P = 0.009). VE/VCO2 optimum cut-off was 17.0 mL/kg/min (sensitivity 70%, specificity 53%) and for AT was 10.5 mL/kg/min (sensitivity 60%, specificity 44%). Multivariable analysis revealed VE/VCO2 to be the only independent factor to predict major morbidity (OR 0.85, 95% CI 0.75–0.97, P = 0.018). Cumulative survival was associated with operative morbidity severity (χ2 = 4.892, df = 1, P = 0.027). These results indicate that VE/VCO2 as derived from CPET is a significant predictor of major morbidity after oesophagectomy highlighting the physiological importance of cardiopulmonary fitness.

    Original languageEnglish
    Article numbere14174
    Number of pages9
    JournalPhysiological Reports
    Volume7
    Issue number14
    DOIs
    Publication statusPublished - 1 Jul 2019

    Keywords

    • Cardiopulmonary fitness
    • esophageal cancer
    • morbidity
    • prognosis

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