Arterial hypoxaemia and its impact on coagulation: significance of altered redox homeostasis

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Abstract

AIMS: Arterial hypoxaemia stimulates free radical formation. Cellular studies suggest this may be implicated in coagulation activation though human evidence is lacking. To examine this, an observational study was designed to explore relationships between systemic oxidative stress and haemostatic responses in healthy participants exposed to inspiratory hypoxia.

RESULTS: Activated partial thromboplastin time and international normalised ratio were measured as routine clinical biomarkers of coagulation and ascorbate free radical (A(•-)) as a direct global biomarker of free radical flux. Six hours of hypoxia activated coagulation, and increased formation of A(•-), with inverse correlations observed against oxyhaemoglobin saturation.

CONCLUSIONS: This is the first study to address the link between free radical formation and coagulation in vivo. This 'proof-of-concept' study demonstrated functional associations between hypoxaemia and coagulation that may be subject to redox activation of the intrinsic pathway. Further studies are required to identify precisely which intrinsic factors are subject to redox activation.

Original languageEnglish
Pages (from-to)752-4
Number of pages3
JournalJournal of Clinical Pathology
Volume68
Issue number9
Early online date4 Jun 2015
DOIs
Publication statusE-pub ahead of print - 4 Jun 2015

Keywords

  • Adult
  • Blood Coagulation
  • Free Radicals
  • Homeostasis
  • Humans
  • Hypoxia
  • Male
  • Oxidation-Reduction
  • Oxidative Stress
  • Observational Study

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