Standard

Applicability of the ACE-III and RBANS cognitive tests for the detection of Alcohol-Related Brain Damage. / Brown, Pamela; Heirene, Robert M; Roderique-Davies, Gareth; John, Bev; Evans, Jonathan.

In: Frontiers in Psychology, Vol. 10, 2636, 28.11.2019.

Research output: Contribution to journalArticle

Harvard

APA

Vancouver

Author

Brown, Pamela ; Heirene, Robert M ; Roderique-Davies, Gareth ; John, Bev ; Evans, Jonathan. / Applicability of the ACE-III and RBANS cognitive tests for the detection of Alcohol-Related Brain Damage. In: Frontiers in Psychology. 2019 ; Vol. 10.

BibTeX

@article{e0c0e2f124f94e6196adcbd8ba9abfd7,
title = "Applicability of the ACE-III and RBANS cognitive tests for the detection of Alcohol-Related Brain Damage",
abstract = "Background: Recent investigations have highlighted the value of neuropsychological testing for the assessment and diagnosis of Alcohol-Related Brain Damage (ARBD).Aims: To evaluate the suitability of the Addenbrooke’s Cognitive Examination (ACE-III) and the Repeatable Battery for the Assessment of Neuropsychological Status (R-BANS) fopr this purpose.Methods: Comparing 28 participants with ARBD (11 Korsakoff’s Syndrome, 17 with ARBD diagnosis) and 30 alcohol-dependent participants without ARBD (ALs), we calculated Area Under the Curve (AUC) statistics, sensitivity and specificity values, base-rate adjusted predictive values, and likelihood ratios for both tests.Results: High levels of diagnostic accuracy were found for the total scores of both the ACE- III (AUC = .823, SE = .056; optimal cut-off ≤86: sensitivity = 82{\%}, specificity = 73{\%}) and R- BANS (AUC = .846, SE = .052; optimal cut-off ≤83: sensitivity = 89{\%}, specificity = 67{\%}) at multiple cut-off points. When participants with a history of polysubstance use were removed from the samples (10 ALs and 1 ARBD), the diagnostic capabilities of the R-BANS improved substantially (AUC = .915, SE = .043; optimal cut-off ≤85: sensitivity = 98{\%}, specificity = 80{\%}), while only minor improvements to the ACE-III’s accuracy was observed (AUC = .854, SE = .056; optimal cut-off ≤88: sensitivity = 85{\%}, specificity = 75{\%}). Both tests produced similar diagnostic values, though the R-BANS was considerably superior with the omission of polysubstance misusers.Conclusions: Overall, the findings suggest both ACE-III and R-BANS are suitable assessment tools for ARBD within an alcohol-dependent population, although the assessment of executive function in both is limited.",
keywords = "ARBD, Korsakoff’s syndrome, neuropsychological assessment, ACE-III, R-BANS, screening, diagnosis",
author = "Pamela Brown and Heirene, {Robert M} and Gareth Roderique-Davies and Bev John and Jonathan Evans",
year = "2019",
month = "11",
day = "28",
doi = "10.3389/fpsyg.2019.02636",
language = "English",
volume = "10",
journal = "Frontiers in Psychology",

}

RIS

TY - JOUR

T1 - Applicability of the ACE-III and RBANS cognitive tests for the detection of Alcohol-Related Brain Damage

AU - Brown, Pamela

AU - Heirene, Robert M

AU - Roderique-Davies, Gareth

AU - John, Bev

AU - Evans, Jonathan

PY - 2019/11/28

Y1 - 2019/11/28

N2 - Background: Recent investigations have highlighted the value of neuropsychological testing for the assessment and diagnosis of Alcohol-Related Brain Damage (ARBD).Aims: To evaluate the suitability of the Addenbrooke’s Cognitive Examination (ACE-III) and the Repeatable Battery for the Assessment of Neuropsychological Status (R-BANS) fopr this purpose.Methods: Comparing 28 participants with ARBD (11 Korsakoff’s Syndrome, 17 with ARBD diagnosis) and 30 alcohol-dependent participants without ARBD (ALs), we calculated Area Under the Curve (AUC) statistics, sensitivity and specificity values, base-rate adjusted predictive values, and likelihood ratios for both tests.Results: High levels of diagnostic accuracy were found for the total scores of both the ACE- III (AUC = .823, SE = .056; optimal cut-off ≤86: sensitivity = 82%, specificity = 73%) and R- BANS (AUC = .846, SE = .052; optimal cut-off ≤83: sensitivity = 89%, specificity = 67%) at multiple cut-off points. When participants with a history of polysubstance use were removed from the samples (10 ALs and 1 ARBD), the diagnostic capabilities of the R-BANS improved substantially (AUC = .915, SE = .043; optimal cut-off ≤85: sensitivity = 98%, specificity = 80%), while only minor improvements to the ACE-III’s accuracy was observed (AUC = .854, SE = .056; optimal cut-off ≤88: sensitivity = 85%, specificity = 75%). Both tests produced similar diagnostic values, though the R-BANS was considerably superior with the omission of polysubstance misusers.Conclusions: Overall, the findings suggest both ACE-III and R-BANS are suitable assessment tools for ARBD within an alcohol-dependent population, although the assessment of executive function in both is limited.

AB - Background: Recent investigations have highlighted the value of neuropsychological testing for the assessment and diagnosis of Alcohol-Related Brain Damage (ARBD).Aims: To evaluate the suitability of the Addenbrooke’s Cognitive Examination (ACE-III) and the Repeatable Battery for the Assessment of Neuropsychological Status (R-BANS) fopr this purpose.Methods: Comparing 28 participants with ARBD (11 Korsakoff’s Syndrome, 17 with ARBD diagnosis) and 30 alcohol-dependent participants without ARBD (ALs), we calculated Area Under the Curve (AUC) statistics, sensitivity and specificity values, base-rate adjusted predictive values, and likelihood ratios for both tests.Results: High levels of diagnostic accuracy were found for the total scores of both the ACE- III (AUC = .823, SE = .056; optimal cut-off ≤86: sensitivity = 82%, specificity = 73%) and R- BANS (AUC = .846, SE = .052; optimal cut-off ≤83: sensitivity = 89%, specificity = 67%) at multiple cut-off points. When participants with a history of polysubstance use were removed from the samples (10 ALs and 1 ARBD), the diagnostic capabilities of the R-BANS improved substantially (AUC = .915, SE = .043; optimal cut-off ≤85: sensitivity = 98%, specificity = 80%), while only minor improvements to the ACE-III’s accuracy was observed (AUC = .854, SE = .056; optimal cut-off ≤88: sensitivity = 85%, specificity = 75%). Both tests produced similar diagnostic values, though the R-BANS was considerably superior with the omission of polysubstance misusers.Conclusions: Overall, the findings suggest both ACE-III and R-BANS are suitable assessment tools for ARBD within an alcohol-dependent population, although the assessment of executive function in both is limited.

KW - ARBD

KW - Korsakoff’s syndrome

KW - neuropsychological assessment

KW - ACE-III

KW - R-BANS

KW - screening

KW - diagnosis

U2 - 10.3389/fpsyg.2019.02636

DO - 10.3389/fpsyg.2019.02636

M3 - Article

C2 - 31849759

VL - 10

JO - Frontiers in Psychology

JF - Frontiers in Psychology

M1 - 2636

ER -

ID: 1835752