Abstract
A synthesis of the tricyclic ring system of the daphnane and tigliane diterpenes, incorporating C-18 and the C-13 oxygen functionality found in phorbol and related compounds is described. The convergent synthesis utilizes an intramolecular Diels-Alder reaction as the key stereocontrolling step.
Original language | English |
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Article number | UNSP 1437-2096,E;2002,0,04,0583,0587,ftx,en;D00502ST.pd |
Pages (from-to) | 583-587 |
Number of pages | 5 |
Journal | Synlett |
Issue number | 4 |
DOIs | |
Publication status | Published - Apr 2002 |
Externally published | Yes |
Keywords
- phorbol
- synthesis
- tigliane
- daphnane
- IMDA
- PROTEIN-KINASE-C
- DIELS-ALDER REACTIONS
- TUMOR PROMOTERS
- FURANS IMDAF
- PHORBOL
- AFFINITY
- SKELETON
- SYSTEMS
- MODEL
- ENTRY