Acute Mountain Sickness and High Altitude Cerebral Oedema

Peter Bärtsch; Damian Miles Bailey

doi:10.1007/978-1-4614-8772-2_20

Acute Mountain Sickness and High Altitude Cerebral Oedema

Peter Bärtsch^*, Damian Miles Bailey

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Citation (Scopus)

Abstract

This chapter summarises advances made over the last 12 years regarding our understanding of the pathophysiology and its clinical implications in acute mountain sickness (AMS) and high altitude cerebral oedema (HACE). Issues on the definition and diagnosis of AMS and HACE as well as determinants of incidence and susceptibility are discussed. Furthermore, new studies on prevention and treatment of AMS are critically evaluated. Findings on lung function, gas, exchange, metabolism, hormonal response, markers of inflammation, changes in the autonomic nervous system, cerebral blood flow, and brain imaging are reviewed. The results of these examinations are incorporated into an overall concept relating to the underlying pathophysiology of acute mountain sickness and high altitude cerebral oedema.

Original language	English
Title of host publication	High Altitude
Subtitle of host publication	Human Adaptation to Hypoxia
Editors	Peter Bärtsch, Erik Swenson
Publisher	Springer
Pages	379-403
Number of pages	25
Volume	9781461487722
ISBN (Electronic)	978-1-4614-8772-2
ISBN (Print)	978-1-4614-8771-5
DOIs	https://doi.org/10.1007/978-1-4614-8772-2_20 https://doi.org/10.1007/978-1-4614-8772-2
Publication status	Published - 1 Jul 2014

Keywords

Hypoxia
HACE
AMS
high altitude cerebral oedema
acute mountain sickness

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title = "Acute Mountain Sickness and High Altitude Cerebral Oedema",

abstract = "This chapter summarises advances made over the last 12 years regarding our understanding of the pathophysiology and its clinical implications in acute mountain sickness (AMS) and high altitude cerebral oedema (HACE). Issues on the definition and diagnosis of AMS and HACE as well as determinants of incidence and susceptibility are discussed. Furthermore, new studies on prevention and treatment of AMS are critically evaluated. Findings on lung function, gas, exchange, metabolism, hormonal response, markers of inflammation, changes in the autonomic nervous system, cerebral blood flow, and brain imaging are reviewed. The results of these examinations are incorporated into an overall concept relating to the underlying pathophysiology of acute mountain sickness and high altitude cerebral oedema. ",

keywords = "Hypoxia, HACE, AMS, high altitude cerebral oedema, acute mountain sickness",

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N2 - This chapter summarises advances made over the last 12 years regarding our understanding of the pathophysiology and its clinical implications in acute mountain sickness (AMS) and high altitude cerebral oedema (HACE). Issues on the definition and diagnosis of AMS and HACE as well as determinants of incidence and susceptibility are discussed. Furthermore, new studies on prevention and treatment of AMS are critically evaluated. Findings on lung function, gas, exchange, metabolism, hormonal response, markers of inflammation, changes in the autonomic nervous system, cerebral blood flow, and brain imaging are reviewed. The results of these examinations are incorporated into an overall concept relating to the underlying pathophysiology of acute mountain sickness and high altitude cerebral oedema.

AB - This chapter summarises advances made over the last 12 years regarding our understanding of the pathophysiology and its clinical implications in acute mountain sickness (AMS) and high altitude cerebral oedema (HACE). Issues on the definition and diagnosis of AMS and HACE as well as determinants of incidence and susceptibility are discussed. Furthermore, new studies on prevention and treatment of AMS are critically evaluated. Findings on lung function, gas, exchange, metabolism, hormonal response, markers of inflammation, changes in the autonomic nervous system, cerebral blood flow, and brain imaging are reviewed. The results of these examinations are incorporated into an overall concept relating to the underlying pathophysiology of acute mountain sickness and high altitude cerebral oedema.

KW - Hypoxia

KW - HACE

KW - AMS

KW - high altitude cerebral oedema

KW - acute mountain sickness

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DO - 10.1007/978-1-4614-8772-2_20

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VL - 9781461487722

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BT - High Altitude

A2 - Bärtsch, Peter

A2 - Swenson, Erik

PB - Springer

ER -

Acute Mountain Sickness and High Altitude Cerebral Oedema

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Keywords

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