Acute Mountain Sickness and High Altitude Cerebral Oedema

Peter Bärtsch*, Damian Miles Bailey

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Citation (Scopus)


This chapter summarises advances made over the last 12 years regarding our understanding of the pathophysiology and its clinical implications in acute mountain sickness (AMS) and high altitude cerebral oedema (HACE). Issues on the definition and diagnosis of AMS and HACE as well as determinants of incidence and susceptibility are discussed. Furthermore, new studies on prevention and treatment of AMS are critically evaluated. Findings on lung function, gas, exchange, metabolism, hormonal response, markers of inflammation, changes in the autonomic nervous system, cerebral blood flow, and brain imaging are reviewed. The results of these examinations are incorporated into an overall concept relating to the underlying pathophysiology of acute mountain sickness and high altitude cerebral oedema.
Original languageEnglish
Title of host publicationHigh Altitude
Subtitle of host publicationHuman Adaptation to Hypoxia
EditorsPeter Bärtsch, Erik Swenson
Number of pages25
ISBN (Electronic)978-1-4614-8772-2
ISBN (Print)978-1-4614-8771-5
Publication statusPublished - 1 Jul 2014


  • Hypoxia
  • HACE
  • AMS
  • high altitude cerebral oedema
  • acute mountain sickness


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