Acute high-intensity interval exercise is less pro-oxidative/thrombotic compared to isovolumic moderate-intensity steady-state exercise

Lewis Fall, Benjamin Stacey, Thomas A. Calverley, Tom Owens, Kaitlin Thyer, Rhodri Griffiths, Rhodri Phillips, Damian Bailey*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

While high-intensity interval training (HIIT) has emerged as a more time-efficient alternative to moderate-intensity steady-state exercise (MISS), the impact on systemic free radical formation and link to activated coagulation remains unknown. We recruited sixteen healthy males aged 21 ± 3 y who performed incremental cycle ergometry to determine peak oxygen uptake ([Formula: see text] PEAK). Participants were randomly assigned single blind to two separate groups (MISS: n = 8; HIIT: n = 8) matched for [Formula: see text] PEAK. HIIT participants completed five exercise cycles, each consisting of 3 min at 80%[Formula: see text] PEAK alternating with 3 min at 40% [Formula: see text] PEAK, whereas MISS participants performed an isovolumic bout of 30 min at 60% [Formula: see text] PEAK. Cephalic venous blood was assayed for ascorbate free radical (A•-, electron paramagnetic resonance spectroscopy) and clot fractal dimension (df, rheometry) at rest every hour over a 6-h period to determine critical difference (CD) and before/after submaximal/peak exercise. Submaximal MISS increased A• - and df to a greater extent compared to HIIT (P = 0.039 to 0.057) although elevations generally fell within CD boundaries (54.2% and 5.5% respectively). No further elevations were observed during peak exercise (P = 0.508 to 0.827) and no relationships were observed between A•- and df (r = 0.435 to - 0.121, P = 0.092 to 0.655). Collectively, these findings suggest that HIIT is less pro-oxidative/thrombotic compared to more traditional MISS, advocating its prescription in patients given the potential for superior vascular adaptive benefit.
Original languageEnglish
JournalJournal of physiology and biochemistry
Volume00
Issue number00
Early online date30 Aug 2022
DOIs
Publication statusE-pub ahead of print - 30 Aug 2022

Keywords

  • hemostasis
  • exercise intensity
  • free radicals
  • coagulation
  • oxygen uptake

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