A convenient preparation of symmetrical and unsymmetrical 1,2-diketones: application to fluorinated phenytoin synthesis

Philip C. Bulman Page; Andrew E. Graham; B. Kevin Park

doi:10.1016/S0040-4020(01)88265-X

A convenient preparation of symmetrical and unsymmetrical 1,2-diketones: application to fluorinated phenytoin synthesis

Philip C. Bulman Page^*, Andrew E. Graham, B. Kevin Park

^*Corresponding author for this work

Faculty of Computing, Engineering and Science

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

1,2-Diketones are efficiently produced in two steps by reaction of aldehydes with anions derived from 2-substituted dithianes followed by treatment of the resulting alcohols with NBS in aqueous acetone; phenytolin derivatives were prepared from these diketones by a standard method involving treatment with urea and potassium hydroxide under reflux.

Original language	English
Pages (from-to)	7265-7274
Number of pages	10
Journal	Tetrahedron Letters
Volume	48
Issue number	35
DOIs	https://doi.org/10.1016/S0040-4020(01)88265-X
Publication status	Published - 1992

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title = "A convenient preparation of symmetrical and unsymmetrical 1,2-diketones: application to fluorinated phenytoin synthesis",

abstract = "1,2-Diketones are efficiently produced in two steps by reaction of aldehydes with anions derived from 2-substituted dithianes followed by treatment of the resulting alcohols with NBS in aqueous acetone; phenytolin derivatives were prepared from these diketones by a standard method involving treatment with urea and potassium hydroxide under reflux. ",

author = "{Bulman Page}, {Philip C.} and Graham, {Andrew E.} and Park, {B. Kevin}",

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T1 - A convenient preparation of symmetrical and unsymmetrical 1,2-diketones

T2 - application to fluorinated phenytoin synthesis

AU - Bulman Page, Philip C.

AU - Graham, Andrew E.

AU - Park, B. Kevin

PY - 1992

Y1 - 1992

N2 - 1,2-Diketones are efficiently produced in two steps by reaction of aldehydes with anions derived from 2-substituted dithianes followed by treatment of the resulting alcohols with NBS in aqueous acetone; phenytolin derivatives were prepared from these diketones by a standard method involving treatment with urea and potassium hydroxide under reflux.

AB - 1,2-Diketones are efficiently produced in two steps by reaction of aldehydes with anions derived from 2-substituted dithianes followed by treatment of the resulting alcohols with NBS in aqueous acetone; phenytolin derivatives were prepared from these diketones by a standard method involving treatment with urea and potassium hydroxide under reflux.

U2 - 10.1016/S0040-4020(01)88265-X

DO - 10.1016/S0040-4020(01)88265-X

M3 - Article

AN - SCOPUS:0026703228

SN - 0040-4039

VL - 48

SP - 7265

EP - 7274

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 35

ER -

A convenient preparation of symmetrical and unsymmetrical 1,2-diketones: application to fluorinated phenytoin synthesis

Abstract

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