A convenient preparation of symmetrical and unsymmetrical 1,2-diketones: application to fluorinated phenytoin synthesis

Philip C. Bulman Page, Andrew E. Graham, B. Kevin Park

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

1,2-Diketones are efficiently produced in two steps by reaction of aldehydes with anions derived from 2-substituted dithianes followed by treatment of the resulting alcohols with NBS in aqueous acetone; phenytolin derivatives were prepared from these diketones by a standard method involving treatment with urea and potassium hydroxide under reflux. 

Original languageEnglish
Pages (from-to)7265-7274
Number of pages10
JournalTetrahedron Letters
Volume48
Issue number35
DOIs
Publication statusPublished - 1992

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