TY - JOUR
T1 - A bis(η5-cyclopentadienyl)cobalt complex of a bis-dithiolene: a chemical analogue of the metal centres of the DMSO reductase family of molybdenum and tungsten enzymes, in particular ferredoxin aldehyde oxidoreductase
AU - Alphonse, France-Aimée
AU - Karim, Rehana
AU - Cano-Soumillac, Céline
AU - Hebray, Marielle
AU - Collison, David
AU - Garner, David
AU - Joule, John
PY - 2005
Y1 - 2005
N2 - The synthesis is described of a bis-ene-1,2-dithiolate pro-ligand, designed to model the stereochemical situation in the cofactor of the tungsten enzyme ferredoxin aldehyde oxidoreductase from Pyrococcus furiosus. Each masked ene-1,2-dithiolate unit is mounted on a pyrano[2,3-b]tetrahydroquinoxaline tricycle, comparable to the pyrano[2,3-g]tetrahydropteridines found in all molybdoenzymes and tungsten analogues. Hydrolytic release of the bis-ligand was confirmed by its entrapment as a double (η5-C5H5)Co complex.
AB - The synthesis is described of a bis-ene-1,2-dithiolate pro-ligand, designed to model the stereochemical situation in the cofactor of the tungsten enzyme ferredoxin aldehyde oxidoreductase from Pyrococcus furiosus. Each masked ene-1,2-dithiolate unit is mounted on a pyrano[2,3-b]tetrahydroquinoxaline tricycle, comparable to the pyrano[2,3-g]tetrahydropteridines found in all molybdoenzymes and tungsten analogues. Hydrolytic release of the bis-ligand was confirmed by its entrapment as a double (η5-C5H5)Co complex.
KW - Aldehyde
KW - Tungsten
KW - Ligand
KW - DMSO reductase family
KW - Pyrano[2,3-b]quinoxaline
KW - Enedithiolate
U2 - 10.1016/j.tet.2005.08.095
DO - 10.1016/j.tet.2005.08.095
M3 - Article
VL - 61
SP - 11010
EP - 11019
JO - Tetrahedron Letters
JF - Tetrahedron Letters
SN - 0040-4039
IS - 46
ER -