A bis(η5-cyclopentadienyl)cobalt complex of a bis-dithiolene: a chemical analogue of the metal centres of the DMSO reductase family of molybdenum and tungsten enzymes, in particular ferredoxin aldehyde oxidoreductase

France-Aimée Alphonse, Rehana Karim, Céline Cano-Soumillac, Marielle Hebray, David Collison, David Garner, John Joule

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The synthesis is described of a bis-ene-1,2-dithiolate pro-ligand, designed to model the stereochemical situation in the cofactor of the tungsten enzyme ferredoxin aldehyde oxidoreductase from Pyrococcus furiosus. Each masked ene-1,2-dithiolate unit is mounted on a pyrano[2,3-b]tetrahydroquinoxaline tricycle, comparable to the pyrano[2,3-g]tetrahydropteridines found in all molybdoenzymes and tungsten analogues. Hydrolytic release of the bis-ligand was confirmed by its entrapment as a double (η5-C5H5)Co complex.

    Original languageEnglish
    Pages (from-to)11010-11019
    Number of pages10
    JournalTetrahedron Letters
    Volume61
    Issue number46
    DOIs
    Publication statusPublished - 2005

    Keywords

    • Aldehyde
    • Tungsten
    • Ligand
    • DMSO reductase family
    • Pyrano[2,3-b]quinoxaline
    • Enedithiolate

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