In this study, the deformation induced by the first wetting typically referred to as wetting deformation of a sandstone–mudstone particle mixture is examined. Wetting deformation can lead to collapse-inducing cracks. The cracks may weaken the strength of the structure. To investigate the first wetting-induced deformation of the sandstone and mudstone particle mixture, three triaxial tests were conducted. Two of the triaxial tests used saturated soil and dry soil. These tests were used to calculate the strain under the condition of minimized deviator stress ratio at wetting. The third triaxial test accesses various deviator stress ratios at wetting. Additionally, the influence on axial and volumetric strain of wetting at varying levels of the confining stress and deviator stress ratios at wetting was evaluated. The wetting axial and volumetric strains were found to increase with an increased confining stress and deviator stress ratio at wetting. The relationships between the wetting axial strain and deviator stress ratio at wetting yielded a logarithmic curve for various levels of confining stress. In contrast, the wetting volumetric strain yielded a direct relationship with the deviator stress ratio at wetting for various levels of confining stress. Based on these results, two equations for predicting the wetting axial and volumetric strains are suggested.