Detailed analysis on the impact of RF and channel impairments on the performance of Ultra-Wideband (UWB) wireless Orthogonal Frequency Division Multiplexing (OFDM) systems based on the IEEE 802.15.3c standard, for high data-rate applications using the 60 GHz millimetre frequency band is presented in this paper. This frequency band, due to the large available bandwidth is very attractive for future and 5G wireless communication systems. The usage of OFDM at millimetre-wave (mmWaves) frequencies is severely affected by non-linearities of the Radio Frequency (RF) front-ends. The impact of impairments is evaluated, in terms of some of the most important key performance indicators, including spectral efficiency, power efficiency, required coding overhead and system complexity, Out-Of-Band Emissions (OOBEs), Bit Error Rate (BER) target and Peak Signal-to-Noise Ratio (PSNR). Additionally, joint distortion effects of coexisting Phase-Noise (PN), mixer IQ imbalances and Power Amplifier (PA) non-linearities, on the performance degradation of a mmWave radio transceiver, combined with various multipath fading channels, are investigated. Subsequently, the power efficiency of the system is evaluated by estimating values of the PA Output-Power-Backoff (OBO) needed to meet the requirements for the Transmit Spectrum Mask (TSM) and BER target. Finally, a comparison of the system overall performance between uncoded and coded OFDM systems combined with Quadrature Amplitude Modulations (16 and 64 QAM) and its maximum operable range are evaluated by transmitting a Full HD uncompressed video frame under five different RF impairment conditions over a typical LOS kiosk 60 GHz IEEE channel model.