The influence of hemoconcentration on hypoxic pulmonary vasoconstriction in acute, prolonged, and lifelong hypoxemia

Mike Stembridge, Ryan L. Hoiland, Alexandra M. Williams, Connor A. Howe, Joseph Donnelly, Tony G. Dawkins, Aimee Drane, Michael M. Tymko, Christopher Gasho, James Anholm, Lydia L. Simpson, Jonathan P. Moore, Damian M. Bailey, David B. MacLeod, Philip N. Ainslie

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

29 Wedi eu Llwytho i Lawr (Pure)

Crynodeb

Red blood cell concentration influences the pulmonary vasculature via direct frictional force and vasoactive signaling, but whether the magnitude of the response is modified with duration of exposure is not known. By assessing the pulmonary vascular response to hemodilution in acute normobaric and prolonged hypobaric hypoxia in lowlanders and lifelong hypobaric hypoxemia in Andean natives, we demonstrated that a reduction in red cell concentration augments the vasoconstrictive effects of hypoxia in lowlanders. In high-altitude natives, hemodilution lowered pulmonary vascular resistance, but a compensatory increase in cardiac output following hemodilution rendered PASP unchanged.
Iaith wreiddiolSaesneg
Rhif yr erthygl00357
Tudalennau (o-i)H738-H747
Nifer y tudalennau10
CyfnodolynAmerican Journal of Physiology - Heart and Circulatory Physiology
Cyfrol321
Rhif cyhoeddi4
Dyddiad ar-lein cynnar28 Medi 2021
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - 1 Hyd 2021

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