Synthesis and Stereochemical Assignment of (+)-Chamuvarinin

Raghava Vanga, G. J. Florence, J. Morris, R. Murray, J. Osler, T. Smith

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

Crynodeb

A stereocontrolled total synthesis of (+)-chamuvarinin, isolated from the root extract of Uvaria Chamae, utilizes a convergent modular strategy to construct the adjacently linked C15-C28 ether array, followed by a late-stage Julia-Kocienski olefination to append the butenolide motif. This constitutes the first total synthesis of (+)-chamuvarinin, defining the relative and absolute configuration of this unique annonaceous acetogenin.
Iaith wreiddiolSaesneg
Tudalennau (o-i)5 - 7
Nifer y tudalennau2
CyfnodolynOrganic Letters
Cyfrol13
Rhif cyhoeddi3
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - 4 Chwef 2011

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