Sequencing of Treatment Modalities for Clinical Management of Premature Ejaculation: Early Results

Martin Steggall, A Pryce, C.G. Fowler, S Coals, F.I. Chinegwundoh

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid


Introduction and objectives
Clinical management of premature ejaculation (PE) can be with behavioural therapies or pharmacological intervention. The reported literature indicates low sustainability with behavioural interventions, and cessation of pharmacological intervention often results in return to baseline levels of intravaginal ejaculatory latency time (IELT). We hypothesised that the sequencing of treatment modalities may help to maintain IELT measures post-intervention.

Participants were randomised to receive paroxetine 20mg daily or Premjact spray™ for 2 months. All men then received a 6-8 week modified behavioural therapy programme. Subjects were asked to measure their IELT using a stopwatch (at home): at baseline, at regular intervals during the pharmacological intervention, at cessation of pharmacological intervention and following behavioural therapy.

Currently 35 men have been recruited to the trial (mean age 40.7 years). 10 men have completed the paroxetine arm and 4 men have completed the Premjact spray™ arm. 10 men are in the pharmacological phase of the trial currently and 11 men have been withdrawn from the trial due to protocol violations (6 failed to attend follow-up appointments), or due to intolerable side effects of the medication (5 withdrew from the paroxetine arm due to gastro-intestinal disturbance or dizziness). The mean pre-intervention stopwatch-assessed IELT was 1min. 10 seconds. After either pharmacological intervention the mean IELT improved to 5min. 51 seconds. The mean improvement in IELT delay was similar for both treatment groups (371 seconds in the Premjact spray™ group and 351 seconds in the paroxetine group). To date, 5 men have completed both phases and all maintained post-pharmacology IELT levels (+/- 25 second change) at 2-months post treatment.

Although too early to comment on the statistical significance of the results, our data illustrates that combining interventions may be useful in maintaining post-pharmacological IELT in men with PE.
Iaith wreiddiolSaesneg
Tudalennau (o-i)112
CyfnodolynJournal of Sex Research
Rhif cyhoeddi2
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - 2008
Cyhoeddwyd yn allanolIe

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