Responses of mouse spinal neurones in culture to locally applied Phe-Met-Arg-Phe-NH2

P. W. McCarthy; G. A. Cottrell

doi:10.1016/0742-8413(84)90218-4

Responses of mouse spinal neurones in culture to locally applied Phe-Met-Arg-Phe-NH2

P. W. McCarthy^*, G. A. Cottrell

^*Awdur cyfatebol y gwaith hwn

Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

19 Dyfyniadau (Scopus)

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1. Embryonic mouse spinal cord neurones were maintained in a primary dissociated culture with a medium free from antibiotics.

2. Intracellular recordings were made and the effects of local application of the neuropeptide FMRFamide were tested on selected neurones. Two types of response were seen.

3. One response was depolarizing, with an accompanying decrease in conductance. This response was probably caused by a reduction in permeability to potassium ions.

4. The second type of response was accompanied by an increase in conductance. Such responses showed a wide variation in their reversal potentials between different neurones. A combination of permeability changes to sodium and chloride ions appeared to be responsible for these responses.

Iaith wreiddiol	Saesneg
Tudalennau (o-i)	383-387
Nifer y tudalennau	5
Cyfnodolyn	Comparative Biochemistry and Physiology. Part C, Comparative Pharmacology
Cyfrol	79
Rhif cyhoeddi	2
Dynodwyr Gwrthrych Digidol (DOIs)	https://doi.org/10.1016/0742-8413(84)90218-4
Statws	Cyhoeddwyd - 1984
Cyhoeddwyd yn allanol	Ie

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10.1016/0742-8413(84)90218-4Trwydded: CC BY-NC-ND

Dyfynnu hyn

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title = "Responses of mouse spinal neurones in culture to locally applied Phe-Met-Arg-Phe-NH2",

abstract = "1. Embryonic mouse spinal cord neurones were maintained in a primary dissociated culture with a medium free from antibiotics. 2. Intracellular recordings were made and the effects of local application of the neuropeptide FMRFamide were tested on selected neurones. Two types of response were seen. 3. One response was depolarizing, with an accompanying decrease in conductance. This response was probably caused by a reduction in permeability to potassium ions. 4. The second type of response was accompanied by an increase in conductance. Such responses showed a wide variation in their reversal potentials between different neurones. A combination of permeability changes to sodium and chloride ions appeared to be responsible for these responses. ",

author = "McCarthy, {P. W.} and Cottrell, {G. A.}",

year = "1984",

doi = "10.1016/0742-8413(84)90218-4",

language = "English",

volume = "79",

pages = "383--387",

journal = "Comparative Biochemistry and Physiology. Part C, Comparative Pharmacology",

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T1 - Responses of mouse spinal neurones in culture to locally applied Phe-Met-Arg-Phe-NH2

AU - McCarthy, P. W.

AU - Cottrell, G. A.

PY - 1984

Y1 - 1984

N2 - 1. Embryonic mouse spinal cord neurones were maintained in a primary dissociated culture with a medium free from antibiotics. 2. Intracellular recordings were made and the effects of local application of the neuropeptide FMRFamide were tested on selected neurones. Two types of response were seen. 3. One response was depolarizing, with an accompanying decrease in conductance. This response was probably caused by a reduction in permeability to potassium ions. 4. The second type of response was accompanied by an increase in conductance. Such responses showed a wide variation in their reversal potentials between different neurones. A combination of permeability changes to sodium and chloride ions appeared to be responsible for these responses.

AB - 1. Embryonic mouse spinal cord neurones were maintained in a primary dissociated culture with a medium free from antibiotics. 2. Intracellular recordings were made and the effects of local application of the neuropeptide FMRFamide were tested on selected neurones. Two types of response were seen. 3. One response was depolarizing, with an accompanying decrease in conductance. This response was probably caused by a reduction in permeability to potassium ions. 4. The second type of response was accompanied by an increase in conductance. Such responses showed a wide variation in their reversal potentials between different neurones. A combination of permeability changes to sodium and chloride ions appeared to be responsible for these responses.

U2 - 10.1016/0742-8413(84)90218-4

DO - 10.1016/0742-8413(84)90218-4

M3 - Article

C2 - 6151471

AN - SCOPUS:0021747593

SN - 0306-4492

VL - 79

SP - 383

EP - 387

JO - Comparative Biochemistry and Physiology. Part C, Comparative Pharmacology

JF - Comparative Biochemistry and Physiology. Part C, Comparative Pharmacology

IS - 2

ER -

Responses of mouse spinal neurones in culture to locally applied Phe-Met-Arg-Phe-NH2

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