Redox Regulation of Post-Prandial Vascular Endothelial Dysfunction

Tyldum et al. (1) elegantly demonstrated that an acute bout of high-intensity interval exercise (HIE) provides superior prophylaxis against post-prandial vascular endothelial dysfunction compared with an isocaloric bout of continuous moderate-intensity exercise. The post-prandial maintenance of brachial artery flowmediated vasodilation was attributed to an enhanced mobilization of antioxidants into the systemic circulation, which was shown to be exercise-intensity dependent. The authors speculated that by neutralizing lipemia-induced oxidative stress, HIE preserved endothelial function subsequent to an increase in vascular nitric oxide (NO) bioavailability. Given the limited assessment of free radical metabolism, I would like to raise some additional points for consideration and indeed proffer an alternative interpretation at least for their metabolic findings. ...