Nanoporous Aluminosilicate Mediated Synthesis of 2- and 2,2-substituted 2,3-Dihydroquinazolin-4(1H)-ones

Matthew Aldred; Fuxuan Li; Rong Kuang; Owen L. Thomas; Thomas Davies; Stuart H. Taylor; Peter Miedziak; Andrew Graham

doi:10.1016/j.tetlet.2024.155037

Nanoporous Aluminosilicate Mediated Synthesis of 2- and 2,2-substituted 2,3-Dihydroquinazolin-4(1H)-ones

Matthew Aldred, Fuxuan Li, Rong Kuang, Owen L. Thomas, Thomas Davies, Stuart H. Taylor, Peter Miedziak, Andrew Graham^*

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Allbwn ymchwil: Cyfraniad at gyfnodolyn › Erthygl › adolygiad gan gymheiriaid

40 Wedi eu Llwytho i Lawr (Pure)

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Nanoporous silicate materials, made by an operationally simple evaporation-induced selfassembly (EISA) approach, efficiently catalyze the formation of 2-substituted 2,3-dihydroquinazolin4(1H)-ones from aldehydes and dimethyl acetals. This methodology can be extended to encompass the reaction of ketones and ketals to provide facile access to 2,2-disubstituted and spiro dihydroquinazolin4(1H)-ones in high yields and short reaction times.

Iaith wreiddiol	Saesneg
Rhif yr erthygl	155037
Nifer y tudalennau	5
Cyfnodolyn	Tetrahedron Letters
Cyfrol	140
Dyddiad ar-lein cynnar	26 Maw 2024
Dynodwyr Gwrthrych Digidol (DOIs)	https://doi.org/10.1016/j.tetlet.2024.155037
Statws	Cyhoeddwyd - 29 Maw 2024

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10.1016/j.tetlet.2024.155037

Quinazolinone Paper final ModifiedLlawysgrif awdur wedi’i dderbyn, 368 KBTrwydded: CC BY-NC-ND

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@article{cad862352ec04a39b7a6f2b38bf64fe5,

title = "Nanoporous Aluminosilicate Mediated Synthesis of 2- and 2,2-substituted 2,3-Dihydroquinazolin-4(1H)-ones",

abstract = "Nanoporous silicate materials, made by an operationally simple evaporation-induced selfassembly (EISA) approach, efficiently catalyze the formation of 2-substituted 2,3-dihydroquinazolin4(1H)-ones from aldehydes and dimethyl acetals. This methodology can be extended to encompass the reaction of ketones and ketals to provide facile access to 2,2-disubstituted and spiro dihydroquinazolin4(1H)-ones in high yields and short reaction times.",

keywords = "Heterogeneous catalysis, dihydroquinazolinones, cyclocondensation, nanoporous aluminosilicates",

author = "Matthew Aldred and Fuxuan Li and Rong Kuang and Thomas, {Owen L.} and Thomas Davies and Taylor, {Stuart H.} and Peter Miedziak and Andrew Graham",

year = "2024",

month = mar,

day = "29",

doi = "10.1016/j.tetlet.2024.155037",

language = "English",

volume = "140",

journal = "Tetrahedron Letters",

issn = "1873-3581",

publisher = "Elsevier",

}

TY - JOUR

T1 - Nanoporous Aluminosilicate Mediated Synthesis of 2- and 2,2-substituted 2,3-Dihydroquinazolin-4(1H)-ones

AU - Aldred, Matthew

AU - Li, Fuxuan

AU - Kuang, Rong

AU - Thomas, Owen L.

AU - Davies, Thomas

AU - Taylor, Stuart H.

AU - Miedziak, Peter

AU - Graham, Andrew

PY - 2024/3/29

Y1 - 2024/3/29

N2 - Nanoporous silicate materials, made by an operationally simple evaporation-induced selfassembly (EISA) approach, efficiently catalyze the formation of 2-substituted 2,3-dihydroquinazolin4(1H)-ones from aldehydes and dimethyl acetals. This methodology can be extended to encompass the reaction of ketones and ketals to provide facile access to 2,2-disubstituted and spiro dihydroquinazolin4(1H)-ones in high yields and short reaction times.

AB - Nanoporous silicate materials, made by an operationally simple evaporation-induced selfassembly (EISA) approach, efficiently catalyze the formation of 2-substituted 2,3-dihydroquinazolin4(1H)-ones from aldehydes and dimethyl acetals. This methodology can be extended to encompass the reaction of ketones and ketals to provide facile access to 2,2-disubstituted and spiro dihydroquinazolin4(1H)-ones in high yields and short reaction times.

KW - Heterogeneous catalysis

KW - dihydroquinazolinones

KW - cyclocondensation

KW - nanoporous aluminosilicates

U2 - 10.1016/j.tetlet.2024.155037

DO - 10.1016/j.tetlet.2024.155037

M3 - Article

SN - 1873-3581

VL - 140

JO - Tetrahedron Letters

JF - Tetrahedron Letters

M1 - 155037

ER -

Nanoporous Aluminosilicate Mediated Synthesis of 2- and 2,2-substituted 2,3-Dihydroquinazolin-4(1H)-ones

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