Metallo-β-cyclodextrins of 6 A-(2-(2-(2-Aminoethylamino)-ethylamino)ethylamino)-6 A-deoxy-β-cyclodextrin 6 A-Deoxy-6 A-(1,4,7,10-tetraazacyclododecan-1-yl)-β-cyclodextrin: Their formation and complexation of (R)- and (S)-tryptophan and tryptophanate in aqueous solution

Suzanna D. Kean, Christopher J. Easton, Stephen F. Lincoln

Allbwn ymchwil: Cyfraniad at gyfnodolynErthygladolygiad gan gymheiriaid

6 Dyfyniadau (Scopus)

Crynodeb

The binary metallo-β-cyclodextrins formed by 6 A-(2-(2-(2-aminoethylamino)ethylamino)ethylamino)-6 A-deoxy-β-cyclodextrin, [M(βCDtrien)] 2+, where M 2+ = Ni 2+, Cu 2+ and Zn 2+, are characterized by log(K/dm 3 mol -1) = 11.50±0.02,10.70±0.07 and 9.40±0.01, respectively, in aqueous solution at 298.2 K and I = 0.1 mol dm -3 (NaClO 4), where K is the stability constant. For those formed by 6 A-deoxy-6 A-(1,4,7,10-tetraazacyclododecan-1-yl)-β-cyclodextrin, [M(βCDcyclen)] 2+, where M 2+ = Cu 2+ and Zn 2+, log(K/dm 3 mol -1) = 13.6±0.02 and 11.62±0.04, respectively. The ternary metallo-β-cyclodextrins formed by [M(βCDtrien)] 2+ and (R)- and (S)-tryptophanate, [M(βCDtrien)((R)-Trp)] + and [M(βCDtrien)((S)-Trp)] + are characterized by log(K/dm 3 mol -1) = 6.90±0.04 and 6.79±0.04, 8.2±0.3 and 7.9±0.2, and 6.64±0.08 and 7.01±0.07, respectively, where M 2+ = Ni 2+, Cu 2+ and Zn 2+. For the ternary metallo-β-cyclodextrins formed by [M(βCDcyclen)] 2+ and (R)- and (S)-tryptophanate, [M(βCDcyclen)((R)-Trp)] + and [M(βCDcyclen)((S)-Trp)] +, log(K/dm 3 mol -1) = 6.84±0.06 and 6.85±0.06, and 4.95±0.05 and 4.94±0.04, respectively, where M 2+ = Cu 2+ and Zn 2+. Other binary and ternary metallo-β-cyclodextrins are also formed. Binary complexes formed by the substituted β-cyclodextrins are exemplified by βCDcyclen (R)-Trp - and βCDcyclen (S)-Trp - for which log(K/dm 3 mol -1) = 3.69±0.04 and 3.95±0.03, respectively. These data are discussed together with those from the literature characterizing other metallo-β-cyclodextrin and substituted β-cyclodextrin systems.

Iaith wreiddiolSaesneg
Tudalennau (o-i)375-381
Nifer y tudalennau7
CyfnodolynAustralian Journal of Chemistry
Cyfrol53
Rhif cyhoeddi5
Dynodwyr Gwrthrych Digidol (DOIs)
StatwsCyhoeddwyd - 1 Rhag 2000
Cyhoeddwyd yn allanolIe

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Gweld gwybodaeth am bynciau ymchwil 'Metallo-β-cyclodextrins of 6 A-(2-(2-(2-Aminoethylamino)-ethylamino)ethylamino)-6 A-deoxy-β-cyclodextrin 6 A-Deoxy-6 A-(1,4,7,10-tetraazacyclododecan-1-yl)-β-cyclodextrin: Their formation and complexation of (R)- and (S)-tryptophan and tryptophanate in aqueous solution'. Gyda’i gilydd, maen nhw’n ffurfio ôl bys unigryw.

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