The objectives of this study were to examine the accounts of Bangladeshi Muslim men with premature ejaculation (PE) and to qualitatively explore self-reported causation. Twenty-three men with either lifelong or acquired PE were interviewed using a semi-structured schedule. Participant's responses were transcribed and analysed using thematic analysis. Three common themes were identified, biomedical, psychological and cultural, that were used to explain PE, with a ‘preference’ for biomedical causation. Each theme had sub-themes that were used to explain ‘acceptable’ forms of sexual practice and subsequent help-seeking behaviours. Using thematic analysis, we identified core themes that appear to characterize the way individuals with PE perceive themselves and their interpersonal relationships. Thematic analysis offers a promising tool to explore how men with PE ‘explain’ their sexual responses to themselves and their partners.