@article{9d7cf27d8cb94e1b8510f875d74aaf1e,
title = "Hypoxemia increases blood-brain barrier permeability during extreme apnea in humans",
abstract = "Voluntary asphyxia imposed by static apnea challenges blood-brain barrier (BBB) integrity in humans through transient extremes of hypertension, hypoxemia and hypercapnia. In the present study, ten ultra-elite breath-hold divers performed two maximal dry apneas preceded by normoxic normoventilation (NX: severe hypoxemia and hypercapnia) and hyperoxic hyperventilation (HX: absence of hypoxemia with exacerbating hypercapnia) with measurements obtained before and immediately after apnea. Transcerebral exchange of NVU proteins (ELISA, Single Molecule Array) were calculated as the product of global cerebral blood flow (gCBF, duplex ultrasound) and radial arterial to internal jugular venous concentration gradients. Apnea duration increased from 5 m 6 s in NX to 15 m 59 s in HX (P =",
keywords = "Hypoxia, blood-brain barrier, cerebral blood flow, hypercapnia, hyperoxia",
author = "Damian Bailey and Bain, {Anthony R.} and Hoiland, {Ryan L.} and Barak, {Otto F.} and Ivan Drvis and Christophe Hirtz and Sylvain Lehmann and Nicola Marchi and Damir Janigro and MacLeod, {David B.} and Philip Ainslie and {\v Z}eljko Duji{\'c}",
note = "Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: DMB was supported by a Royal Society Wolfson Research Fellowship (#WM170007), Royal Society International Exchanges Award (#IES\R2\192137), Japan Society for the Promotion of Science (#JSPS/OF317) and Higher Education Funding Council for Wales. PNA was funded by a Canada Research Chair (CRC) and Natural Sciences and Engineering Research Council of Canada (NSERC) Discovery grant. ARB was funded through a NSERC postdoctoral fellowship. RLH was funded by a NSERC grant. OFB was funded by the Autonomic Province of Vojvodina, Serbia (#142-451-2541). NM was supported by ANR-Hepatobrain, ANR-Epicyte, ERaNet Neu-Vasc, ANSES Epidemicmac and MUSE-iSite University of Montpellier. OFB, ID, PNA and ZD were funded by a Croatian Science Foundation Grant (#IP-2014-09-1937). Acknowledgements Publisher Copyright: {\textcopyright} The Author(s) 2022.",
year = "2022",
month = apr,
day = "11",
doi = "10.1177/0271678X221075967",
language = "English",
volume = "42",
pages = "1120--1135",
journal = "Journal of Cerebral Blood Flow and Metabolism",
issn = "0271-678X",
publisher = "SAGE Publications",
number = "6",
}