Early development and unstable genes in schizophrenia: preliminary results

Agnes Ayton; Alex G Morris; Philip J Tyson; David Hunt; Ann M. Mortimer; David Cottrell

doi:10.1016/S0924-9338(02)00691-0

Early development and unstable genes in schizophrenia: preliminary results

Agnes Ayton, Alex G Morris, Philip J Tyson, David Hunt, Ann M. Mortimer, David Cottrell

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BACKGROUND: Trinucleotide repeats have been associated with schizophrenia, but the evidence, based on cross-sectional clinical information, is equivocal.

AIMS: To examine the relationship between genomic CAG/CTG repeat size and premorbid development in schizophrenia.

METHOD: Early development and premorbid functioning of 22 patients with DSM-IV diagnosis of schizophrenia were assessed by parental interviews. Repeat expansion detection (RED) technique was used to measure genomic CAG/CTG repeat size, and PCR for CAG repeat size at the ERDA-1 and CTG 18.1 loci.

RESULTS: There was an inverse association between CAG/CTG size and perinatal complications. Patients with speech and motor developmental delay had larger repeats. The results were not due to expansion in the ERDA-1 and CTG 18.1 genes.

CONCLUSIONS: CAG/CTG repeat expansion is associated with speech and motor developmental delay in schizophrenia. We propose that the developmental model may be useful for research into the genetics of schizophrenia.

Iaith wreiddiol	Saesneg
Tudalennau (o-i)	332-8
Nifer y tudalennau	7
Cyfnodolyn	European Psychiatry
Cyfrol	17
Rhif cyhoeddi	6
Dynodwyr Gwrthrych Digidol (DOIs)	https://doi.org/10.1016/S0924-9338(02)00691-0
Statws	Cyhoeddwyd - Hyd 2002

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10.1016/S0924-9338(02)00691-0Trwydded: CC BY-NC-ND

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@article{b962eb3b095045b4a411bd24b9714005,

title = "Early development and unstable genes in schizophrenia: preliminary results",

abstract = "BACKGROUND: Trinucleotide repeats have been associated with schizophrenia, but the evidence, based on cross-sectional clinical information, is equivocal.AIMS: To examine the relationship between genomic CAG/CTG repeat size and premorbid development in schizophrenia.METHOD: Early development and premorbid functioning of 22 patients with DSM-IV diagnosis of schizophrenia were assessed by parental interviews. Repeat expansion detection (RED) technique was used to measure genomic CAG/CTG repeat size, and PCR for CAG repeat size at the ERDA-1 and CTG 18.1 loci.RESULTS: There was an inverse association between CAG/CTG size and perinatal complications. Patients with speech and motor developmental delay had larger repeats. The results were not due to expansion in the ERDA-1 and CTG 18.1 genes.CONCLUSIONS: CAG/CTG repeat expansion is associated with speech and motor developmental delay in schizophrenia. We propose that the developmental model may be useful for research into the genetics of schizophrenia.",

keywords = "Adult, Age Factors, Child, Cross-Sectional Studies, Developmental Disabilities, Female, Gene Deletion, Gene Expression, Humans, Male, Motor Skills Disorders, Polymerase Chain Reaction, Retrospective Studies, Schizophrenia, Speech Disorders, Trinucleotide Repeat Expansion, Trinucleotide Repeats",

author = "Agnes Ayton and Morris, {Alex G} and Tyson, {Philip J} and David Hunt and Mortimer, {Ann M.} and David Cottrell",

year = "2002",

month = oct,

doi = "10.1016/S0924-9338(02)00691-0",

language = "English",

volume = "17",

pages = "332--8",

journal = "European Psychiatry",

issn = "0924-9338",

publisher = "Elsevier",

number = "6",

}

TY - JOUR

T1 - Early development and unstable genes in schizophrenia

T2 - preliminary results

AU - Ayton, Agnes

AU - Morris, Alex G

AU - Tyson, Philip J

AU - Hunt, David

AU - Mortimer, Ann M.

AU - Cottrell, David

PY - 2002/10

Y1 - 2002/10

N2 - BACKGROUND: Trinucleotide repeats have been associated with schizophrenia, but the evidence, based on cross-sectional clinical information, is equivocal.AIMS: To examine the relationship between genomic CAG/CTG repeat size and premorbid development in schizophrenia.METHOD: Early development and premorbid functioning of 22 patients with DSM-IV diagnosis of schizophrenia were assessed by parental interviews. Repeat expansion detection (RED) technique was used to measure genomic CAG/CTG repeat size, and PCR for CAG repeat size at the ERDA-1 and CTG 18.1 loci.RESULTS: There was an inverse association between CAG/CTG size and perinatal complications. Patients with speech and motor developmental delay had larger repeats. The results were not due to expansion in the ERDA-1 and CTG 18.1 genes.CONCLUSIONS: CAG/CTG repeat expansion is associated with speech and motor developmental delay in schizophrenia. We propose that the developmental model may be useful for research into the genetics of schizophrenia.

AB - BACKGROUND: Trinucleotide repeats have been associated with schizophrenia, but the evidence, based on cross-sectional clinical information, is equivocal.AIMS: To examine the relationship between genomic CAG/CTG repeat size and premorbid development in schizophrenia.METHOD: Early development and premorbid functioning of 22 patients with DSM-IV diagnosis of schizophrenia were assessed by parental interviews. Repeat expansion detection (RED) technique was used to measure genomic CAG/CTG repeat size, and PCR for CAG repeat size at the ERDA-1 and CTG 18.1 loci.RESULTS: There was an inverse association between CAG/CTG size and perinatal complications. Patients with speech and motor developmental delay had larger repeats. The results were not due to expansion in the ERDA-1 and CTG 18.1 genes.CONCLUSIONS: CAG/CTG repeat expansion is associated with speech and motor developmental delay in schizophrenia. We propose that the developmental model may be useful for research into the genetics of schizophrenia.

KW - Adult

KW - Age Factors

KW - Child

KW - Cross-Sectional Studies

KW - Developmental Disabilities

KW - Female

KW - Gene Deletion

KW - Gene Expression

KW - Humans

KW - Male

KW - Motor Skills Disorders

KW - Polymerase Chain Reaction

KW - Retrospective Studies

KW - Schizophrenia

KW - Speech Disorders

KW - Trinucleotide Repeat Expansion

KW - Trinucleotide Repeats

U2 - 10.1016/S0924-9338(02)00691-0

DO - 10.1016/S0924-9338(02)00691-0

M3 - Article

C2 - 12457743

VL - 17

SP - 332

EP - 338

JO - European Psychiatry

JF - European Psychiatry

SN - 0924-9338

IS - 6

ER -

Early development and unstable genes in schizophrenia: preliminary results

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