The aim of this paper is to explore e-learning’s potential as a change agent for higher education using an e-learning project, E-College Wales (ECW), as a case study. E-College Wales was a large scale, four-year, longitudinal project which provided a good opportunity to evaluate the potential of e-learning as an institution-wide change agent in higher education practices. The findings of this case study are reported via the five dimensions for sustainable implementation of e-learning, namely learning and teaching, organisation, technology, culture, and strategy and management. The methodology used was qualitative and the data collection methods included interviews and focus groups with the tutors and management of the University at both the beginning and the end of the project. These included looking at their attitudes in their own teaching and learning practice, as well as the way e-learning was managed as part of the University’s strategy, in order to compare their expectations with what they experienced. The findings from the ECW project showed that e-learning triggered some initial but vital changes to the University—such as pedagogical discussion that has long been absent—and introduced a more student-centred learning model, new organisational structure and procedures to support technology-enhanced learning, and a clear vision and culture that are more responsive to change.